Evidence map›Paper›PMID 35745101›Full record

ArticleNutrients2022

Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.

Rakesh Radhakrishnan, Matthias Leung, Heidi Roehrich, Stephen Walterhouse, Altaf A Kondkar, Wayne Fitzgibbon, Manas R Biswal, Glenn P Lobo

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Loss of the vitamin A receptor RBPR2 in mice disrupts whole-body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rakesh RadhakrishnanDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Lions Research Building, 2001 6th Street SE, Minneapolis, MN 55455, USA.
Matthias LeungDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Lions Research Building, 2001 6th Street SE, Minneapolis, MN 55455, USA.
Heidi RoehrichDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Lions Research Building, 2001 6th Street SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-2232-9494
Stephen WalterhouseDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Altaf A KondkarGlaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5516-6951
Wayne FitzgibbonDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Manas R BiswalDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-9685-2923
Glenn P LoboDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Lions Research Building, 2001 6th Street SE, Minneapolis, MN 55455, USA.
University of Minnesota · USMedical University of South Carolina · USKing Saud University · SAUniversity of South Florida · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Physiological Role of the Vitamin A Transporter RBPR2 for VisionR01EY030889 · NEI · UNIVERSITY OF MINNESOTA · PI LOBO, GLENN P · 2020 to 2024
$1.8M
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationR00EY027013 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI BISWAL, MANAS R · 2019 to 2021
$960k
Physiological Role of the Zebrafish Retinol Receptor rbpr2 in VisionR21EY025034 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LOBO, GLENN P · 2015 to 2016
$436k
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationK99EY027013 · NEI · UNIVERSITY OF FLORIDA · PI BISWAL, MANAS R · 2016 to 2017
$258k
NCATS NIH HHS UL1 TR001450NEI NIH HHS EY025034NEI NIH HHS EY030889NEI NIH HHS K99 EY027013NEI NIH HHS R00 EY027013NEI NIH HHS R01 EY030889NEI NIH HHS R21 EY025034
6 · The paper itself

Abstract

The systemic transport of dietary vitamin A/all-

Indexed as

RetinoidsVitamin AAnimalsCarrier ProteinsMammalsMiceMice, KnockoutRetinaRetinol-Binding ProteinsZebrafishCarrier ProteinsRetinoidsRetinol-Binding ProteinsVitamin Aall-trans retinolphotoreceptorsRBP4RBPR2retinol-binding protein 4 receptor 2STRA6visual functionvitamin A

Identifiers

PMID35745101
PMCPMC9231411
OpenAlexW4282835673

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.