Evidence map›Paper›PMID 35745668›Full record

ReviewPharmaceuticals (Basel, Switzerland)2022

Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review.

Diane Merino, Arnaud Fernandez, Alexandre O Gérard, Nouha Ben Othman, Fanny Rocher, Florence Askenazy, Céline Verstuyft, Milou-Daniel Drici, Susanne Thümmler

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genetic PolymorphismsPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Signal mining and risk analysis of olanzapine adverse events in the FAERS database.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diane MerinoDepartment of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, 06200 Nice, France.ORCID 0000-0001-7669-2339
Arnaud FernandezDepartment of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, 06200 Nice, France.ORCID 0000-0002-6326-9096
Alexandre O GérardDepartment of Pharmacology and Pharmacovigilance Center, University Hospital of Nice, 06000 Nice, France.ORCID 0000-0001-6591-6966
Nouha Ben OthmanDepartment of Pharmacology and Pharmacovigilance Center, University Hospital of Nice, 06000 Nice, France.
Fanny RocherDepartment of Pharmacology and Pharmacovigilance Center, University Hospital of Nice, 06000 Nice, France.
Florence AskenazyDepartment of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, 06200 Nice, France.
Céline VerstuyftService de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, Groupe Hospitalier Paris Saclay, AP-HP, 94270 Le Kremlin-Bicêtre, France.
Milou-Daniel DriciDepartment of Pharmacology and Pharmacovigilance Center, University Hospital of Nice, 06000 Nice, France.ORCID 0000-0003-4121-530X
Susanne ThümmlerDepartment of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, 06200 Nice, France.ORCID 0000-0001-9993-6981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children and youth treated with antipsychotic drugs (APs) are particularly vulnerable to adverse drug reactions (ADRs) and prone to poor treatment response. In particular, interindividual variations in drug exposure can result from differential metabolism of APs by cytochromes, subject to genetic polymorphism.

Indexed as

adverse drug reactionantipsychoticschildrenclozapineCYP1A2cytochromesloxapineolanzapinepharmacogeneticsyouth

Identifiers

PMID35745668
PMCPMC9230864

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.