ReviewPharmaceutics2022
Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair.
Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- ROS/pH-Responsive Phenylboronic Acid-Chitosan Nanoparticles Improve Silymarin-Mediated Hepatoprotection After Hepatectomy With Gut-Liver Axis-Associated Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Polysaccharides and carbohydrate polymers: innovations from nature to industry.Journal of the science of food and agriculture · 2026Review
- L-Arginine-Modified Chitosan Curcumin Nanocrystals Target M1 Macrophages via CAT-2/Clathrin-Mediated Endocytosis for Mitochondrial Protection and ALI/ARDS Therapy.Pharmaceutics · 2026Article
- The Potential of α-Mangostin-Loaded Chitosan/Collagen Nanoparticles in Hydrogel Formulation for Enhanced Wound Healing.Nanotechnology, science and applications · 2026Article
- Chitosan nanoparticles: Green synthesis, biological activities, and sustainable frontiers in targeted drug delivery and cancer nanomedicine - A comprehensive review.Materials today. Bio · 2025Review
- Harnessing Algae-Derived Bioactive Compounds for Sustainable and Effective Photoprotection in Skincare.Applied biochemistry and biotechnology · 2025Review
- Nisin or Chitosan Enhance the Antimicrobial Activity of Ceftiofur Against Antibiotic-ResistantPathogens (Basel, Switzerland) · 2025Article
- Synergistic Therapeutic Effects of Chitosan and Royal Jelly.Polymers · 2025Review
- Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications.Antioxidants (Basel, Switzerland) · 2025Review
- A Biopolymeric Dextran-Chitosan Delivery System for Controlled Release of Antioxidant and Anti-Inflammatory Compounds: Lignin and Curcumin.Molecules (Basel, Switzerland) · 2025Article
- Films Based on Chitosan/Konjac Glucomannan Blend Containing Resveratrol for Potential Skin Application.Materials (Basel, Switzerland) · 2025Article
- Functional Chitosan and Its Derivative-Related Drug Delivery Systems for Nano-Therapy: Recent Advances.Pharmaceutics · 2024Review
- A TA/CuInternational journal of nanomedicine · 2024Article
- Research and Application of Chitosan Nanoparticles in Orthopedic Infections.International journal of nanomedicine · 2024Review
- Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia.Drug delivery · 2023Article
- Chitosan-Glycolic Acid Gel Modification of Chloride Ion Transport in Mammalian Skin: An In Vitro Study.Molecules (Basel, Switzerland) · 2023Article
- Fabrication and Properties of the Multifunctional Rapid Wound HealingMolecules (Basel, Switzerland) · 2023Article
- Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans.Polymers · 2023Article
- Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan.Frontiers in bioengineering and biotechnology · 2023Article
- Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes.Pharmaceutics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chitosan displays a dual function, acting as both an active ingredient and/or carrier for pharmaceutical bioactive molecules and metal ions. Its hydroxyl- and amino-reactive groups and acetylation degree can be used to adjust this biopolymer's physicochemical and pharmacological properties in different forms, including scaffolds, nanoparticles, fibers, sponges, films, and hydrogels, among others. In terms of pharmacological purposes, chitosan association with different polymers and the immobilization or entrapment of bioactive agents are effective strategies to achieve desired biological responses. Chitosan biocompatibility, water entrapment within nanofibrils, antioxidant character, and antimicrobial and anti-inflammatory properties, whether enhanced by other active components or not, ensure skin moisturization, as well as protection against bacteria colonization and oxidative imbalance. Chitosan-based nanomaterials can maintain or reconstruct skin architecture through topical or systemic delivery of hydrophilic or hydrophobic pharmaceuticals at controlled rates to treat skin affections, such as acne, inflammatory manifestations, wounds, or even tumorigenesis, by coating chemotherapy drugs. Herein, chitosan obtention, physicochemical characteristics, chemical modifications, and interactions with bioactive agents are presented and discussed. Molecular mechanisms involved in chitosan skin protection and recovery are highlighted by overlapping the events orchestrated by the signaling molecules secreted by different cell types to reconstitute healthy skin tissue structures and components.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.