Evidence map›Paper›PMID 35746389›Full record

ArticleSensors (Basel, Switzerland)2022

Early-Stage Alzheimer's Disease Categorization Using PET Neuroimaging Modality and Convolutional Neural Networks in the 2D and 3D Domains.

Ahsan Bin Tufail, Nazish Anwar, Mohamed Tahar Ben Othman, Inam Ullah, Rehan Ali Khan, Yong-Kui Ma, Deepak Adhikari, Ateeq Ur Rehman, Muhammad Shafiq, Habib Hamam

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahsan Bin TufailSchool of Electronics and Information Engineering, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0002-1371-7647
Nazish AnwarRegistered Medical Practitioner, Pakistan Medical Commission, Islamabad 44000, Pakistan.
Mohamed Tahar Ben OthmanDepartment of Computer Science, College of Computer, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0002-0990-5805
Inam UllahCollege of Internet of Things (IoT) Engineering, Changzhou Campus, Hohai University (HHU), Changzhou 213022, China.
Rehan Ali KhanDepartment of Electrical Engineering, University of Science and Technology Bannu, Bannu 28100, Pakistan.ORCID 0000-0001-8917-9278
Yong-Kui MaSchool of Electronics and Information Engineering, Harbin Institute of Technology, Harbin 150001, China.
Deepak AdhikariSchool of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China.
Ateeq Ur RehmanDepartment of Electrical Engineering, Government College University Lahore, Lahore 54000, Pakistan.ORCID 0000-0001-5203-0621
Muhammad ShafiqDepartment of Information and Communication Engineering, Yeungnam University, Gyeongsan 38541, Korea.ORCID 0000-0001-7337-7608
Habib HamamFaculty of Engineering, Université de Moncton, Moncton, NB E1A3E9, Canada.ORCID 0000-0002-5320-1012

Funding

Qassim University Deanship of Scientific Research
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is a health apprehension of significant proportions that is negatively impacting the ageing population globally. It is characterized by neuronal loss and the formation of structures such as neurofibrillary tangles and amyloid plaques in the early as well as later stages of the disease. Neuroimaging modalities are routinely used in clinical practice to capture brain alterations associated with AD. On the other hand, deep learning methods are routinely used to recognize patterns in underlying data distributions effectively. This work uses Convolutional Neural Network (CNN) architectures in both 2D and 3D domains to classify the initial stages of AD into AD, Mild Cognitive Impairment (MCI) and Normal Control (NC) classes using the positron emission tomography neuroimaging modality deploying data augmentation in a random zoomed in/out scheme. We used novel concepts such as the blurring before subsampling principle and distant domain transfer learning to build 2D CNN architectures. We performed three binaries, that is, AD/NC, AD/MCI, MCI/NC and one multiclass classification task AD/NC/MCI. The statistical comparison revealed that 3D-CNN architecture performed the best achieving an accuracy of 89.21% on AD/NC, 71.70% on AD/MCI, 62.25% on NC/MCI and 59.73% on AD/NC/MCI classification tasks using a five-fold cross-validation hyperparameter selection approach. Data augmentation helps in achieving superior performance on the multiclass classification task. The obtained results support the application of deep learning models towards early recognition of AD.

Indexed as

Alzheimer DiseaseCognitive DysfunctionHumansMagnetic Resonance ImagingNeural Networks, ComputerNeuroimagingPositron-Emission TomographyAlzheimer’s diseasebinary classificationdata augmentationdeep learningmulticlass classificationpositron emission tomographystatistical evaluation

Identifiers

PMID35746389
PMCPMC9230850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.