Evidence map›Paper›PMID 35747513›Full record

ArticleDisease markers2022

GSK3B Overexpression Alleviates Posttraumatic Osteoarthritis in Mice by Promoting DNMT1-Mediated Hypermethylation of NR4A3 Promoter.

Zhou Lv, Deping Sun, Xin Li, Gang Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zhou LvOrthopedic Resident Standardized Training, Qingdao Municipal Hospital (Group), Qingdao 266000, China.
Deping SunDepartment of Orthopedic Trauma, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264000, China.
Xin LiDepartment of Rheumatology, 1st Affiliated Hospital of Jin Zhou Medical University, Jinzhou, 121000, China.ORCID https://orcid.org/0000-0002-9492-5412
Gang WuDepartment of General Surgery, 1st Affiliated Hospital of Jin Zhou Medical University, Jinzhou, 121000, China.ORCID https://orcid.org/0000-0002-6655-8731
Affiliated Hospital of Jining Medical University · CNBinzhou Medical University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glycogen synthase kinase 3 Methods: GSK3B expression in the cartilage tissue of PTOA patients was analyzed by western blotting. IL-1 Results: The expression of GSK3B protein was downregulated in PTOA patients. GSK3B overexpression alleviated IL-1 Conclusion: GSK3B recruits DNMT1 to the NR4A3 promoter region and inhibits the activation of the NR4A3-mediated JAK2/STAT3 signaling pathway, thereby alleviating PTOA.

Indexed as

OsteoarthritisReceptors, SteroidAnimalsCells, CulturedChondrocytesCollagen Type IIDNA-Binding ProteinsGlycogen Synthase Kinase 3 betaHumansInterleukin-1betaMiceNerve Tissue ProteinsPromoter Regions, GeneticReceptors, Thyroid HormoneCollagen Type IIDNA-Binding ProteinsGlycogen Synthase Kinase 3 betaGSK3B protein, humanInterleukin-1betaNerve Tissue ProteinsNR4A3 protein, humanNr4a3 protein, mouseReceptors, SteroidReceptors, Thyroid Hormone

Identifiers

PMID35747513
PMCPMC9213187
OpenAlexW4282830908

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.