Evidence map›Paper›PMID 35753846›Full record

ArticleTrends in pharmacological sciences2022

The calcium channel terminator: hasta la vista pain.

Erika K Harding, Gerald W Zamponi

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Marine drugs · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Erika K HardingDepartment of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Gerald W ZamponiDepartment of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address: zamponi@ucalgary.ca.
Alberta Children's Hospital · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain remains a major burden and is difficult to treat. N-type calcium channels may be a suitable therapeutic target for analgesics, and a new study from Colecraft and colleagues utilizes a clever new way to modulate their expression to achieve therapeutic benefits in preclinical models of neuropathic pain.

Indexed as

Chronic PainNeuralgiaAnalgesicsCalcium Channel BlockersCalcium Channels, N-TypeHumansAnalgesicsCalcium Channel BlockersCalcium Channels, N-Typebeta subunitcalcium channelpainubiquitination

Identifiers

PMID35753846
OpenAlexW4283388084

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.