Evidence map›Paper›PMID 35756659›Full record

ArticleFrontiers in oncology2022

Ferroptosis-Related Long Noncoding RNAs as Prognostic Biomarkers for Ovarian Cancer.

Kaili Wang, Shanshan Mei, Mengcheng Cai, Dongxia Zhai, Danying Zhang, Jin Yu, Zhexin Ni, Chaoqin Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kaili WangDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Shanshan MeiDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Mengcheng CaiDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Dongxia ZhaiDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Danying ZhangDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Jin YuDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Zhexin NiDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Chaoqin YuDepartment of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Shanghai University of Traditional Chinese Medicine · CNInternational Peace Maternity & Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is a highly malignant gynecologic tumor with few treatments available and poor prognosis with the currently available diagnostic markers and interventions. More effective methods for diagnosis and treatment are urgently needed. Although the current evidence implicates ferroptosis in the development and therapeutic responses of various types of tumors, it is unclear to what extent ferroptosis affects OC. To explore the potential of ferroptosis-related genes as biomarkers and molecular targets for OC diagnosis and intervention, this study collected several datasets from The Cancer Genome Atlas-OC (TCGA-OC), analyzed and identified the coexpression profiles of 60 ferroptosis-related genes and two subtypes of OC with respect to ferroptosis and further examined and analyzed the differentially expressed genes between the two subtypes. The results indicated that the expression levels of ferroptosis genes were significantly correlated with prognosis in patients with OC. Single-factor Cox and LASSO analysis identified eight lncRNAs from the screened ferroptosis-related genes, including lncRNAs RP11-443B7.3, RP5-1028K7.2, TRAM2-AS1, AC073283.4, RP11-486G15.2, RP11-95H3.1, RP11-958F21.1, and AC006129.1. A risk scoring model was constructed from the ferroptosis-related lncRNAs and showed good performance in the evaluation of OC patient prognosis. The high- and low-risk groups based on tumor scores presented obvious differences in clinical characteristics, tumor mutation burden, and tumor immune cell infiltration, indicating that the risk score has a good ability to predict the benefit of immunotherapy and may provide data to support the implementation of precise immunotherapy for OC. Although

Indexed as

biomarkersferroptosislong noncoding RNAovarian cancertumor immune

Identifiers

PMID35756659
PMCPMC9218568
OpenAlexW4285744317

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.