Evidence map›Paper›PMID 35757202›Full record

ArticleFrontiers in psychiatry2022

Social Isolation and Incident Dementia in the Oldest-Old-A Competing Risk Analysis.

Jessica Grothe, Susanne Röhr, Melanie Luppa, Alexander Pabst, Luca Kleineidam, Kathrin Heser, Angela Fuchs, Michael Pentzek, Anke Oey, Birgitt Wiese and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 2 countries.

Jessica GrotheMedical Faculty, Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Susanne RöhrMedical Faculty, Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Melanie LuppaMedical Faculty, Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Alexander PabstMedical Faculty, Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Luca KleineidamDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Kathrin HeserDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Angela FuchsInstitute of General Practice (ifam), Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Michael PentzekInstitute of General Practice (ifam), Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Anke OeyInstitute of General Practice, Hannover Medical School, Hannover, Germany.
Birgitt WieseInstitute of General Practice, Hannover Medical School, Hannover, Germany.
Dagmar LühmannDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hendrik van den BusscheDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Siegfried WeyererCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jochen WerleCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dagmar WeegDepartment of Psychiatry, Technical University of Munich, Munich, Germany.
Horst BickelDepartment of Psychiatry, Technical University of Munich, Munich, Germany.
Martin SchererDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hans-Helmut KönigDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
André HajekDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Michael WagnerDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Steffi G Riedel-HellerMedical Faculty, Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Leipzig University · DEUniversity Medical Center Hamburg-Eppendorf · DEHeinrich Heine University Düsseldorf · DEMedizinische Hochschule Hannover · DETechnical University of Munich · DEUniversity of Bonn · DECentral Institute of Mental Health · DEGerman Center for Neurodegenerative Diseases · DETrinity College Dublin · IEUniversität Hamburg · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Social isolation is considered a risk factor for dementia. However, less is known about social isolation and dementia with respect to competing risk of death, particularly in the oldest-old, who are at highest risk for social isolation, dementia and mortality. Therefore, we aimed to examine these associations in a sample of oldest-old individuals. Methods: Analyses were based on follow-up (FU) 5-9 of the longitudinal German study AgeCoDe/AgeQualiDe. Social isolation was assessed using the short form of the Lubben Social Network Scale (LSNS-6), with a score ≤ 12 indicating social isolation. Structured interviews were used to identify dementia cases. Competing risk analysis based on the Fine-Gray model was conducted to test the association between social isolation and incident dementia. Results: Excluding participants with prevalent dementia, Conclusion: In contrast to the findings of previous studies, we did not find an association between social isolation and incident dementia in the oldest-old. However, our analysis took into account the competing risk of death and the FU period was rather short. Future studies, especially with longer FU periods and more comprehensive assessment of qualitative social network characteristics (e.g., loneliness and satisfaction with social relationships) may be useful for clarification.

Indexed as

competing risk analysisepidemiologyincident dementialongitudinal studyoldest-oldsocial isolation

Identifiers

PMID35757202
PMCPMC9226337
OpenAlexW4281738956

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.