Evidence map›Paper›PMID 35758040›Full record

ArticleCirculation2022

Novel Smooth Muscle Ca

Yen-Lin Chen, Zdravka Daneva, Maniselvan Kuppusamy, Matteo Ottolini, Thomas M Baker, Eliska Klimentova, Soham A Shah, Jennifer D Sokolowski, Min S Park, Swapnil K Sonkusare

Open access · greenAbstract read
In one paragraph

Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  7. Article
  8. Article
  9. Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yen-Lin ChenRobert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.
Zdravka Daneva *Robert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.
Maniselvan Kuppusamy *Robert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.
Matteo OttoliniRobert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.
Thomas M BakerRobert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.
Eliska KlimentovaRobert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.
Soham A ShahBiomedical Engineering (S.A.S.), University of Virginia, Charlottesville.ORCID 0000-0002-7622-0603
Jennifer D SokolowskiDepartments of Neurosurgery (J.D.S., M.S.P.), University of Virginia, Charlottesville.
Min S ParkDepartments of Neurosurgery (J.D.S., M.S.P.), University of Virginia, Charlottesville.
Swapnil K SonkusareRobert M. Berne Cardiovascular Research Center (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.), University of Virginia, Charlottesville.ORCID 0000-0001-9587-9342
University of Virginia · USBaker Engineering (United States) · US

Funding

Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesityR01HL142808 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$4.4M
Flow-Activated Calcium Signaling Microdomains in Small Pulmonary ArteriesR01HL146914 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$3.8M
New Signaling Networks in Vascular Smooth MuscleR01HL147555 · NHLBI · UNIVERSITY OF VIRGINIA · PI DEREWENDA, ZYGMUNT S, SOMLYO, AVRIL V. · 2020 to 2024
$3.6M
NHLBI NIH HHS R01 HL142808NHLBI NIH HHS R01 HL146914NHLBI NIH HHS R01 HL147555
6 · The paper itself

Abstract

backgroundCa

methodsWe used SMC-specific TRPV4

resultsWe provide first evidence that TRPV4

conclusionsOur data identify novel smooth muscle Ca

Indexed as

HypertensionTRPV Cation ChannelsAnimalsBlood PressureCalcium SignalingLarge-Conductance Calcium-Activated Potassium ChannelsMiceMuscle, Smooth, VascularMyocytes, Smooth MuscleProtein Kinase C-alphaLarge-Conductance Calcium-Activated Potassium ChannelsProtein Kinase C-alphaTrpv4 protein, mouseTRPV Cation Channelsblood pressurecalcium signalinghypertensionion channelsmonocytes, smooth muscle

Identifiers

PMID35758040
PMCPMC9378684
OpenAlexW4283654038

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.