Evidence map›Paper›PMID 35759035›Full record

ArticleApplied microbiology and biotechnology2022

Development of an immunogen containing CD4

Isabela de Andrade Ferraz, Ana Maria Ravena Severino Carvalho, Rory Cristiane Fortes de Brito, Bruno Mendes Roatt, Vívian Tamietti Martins, Daniela Pagliara Lage, Luiza Dos Reis Cruz, Fernanda Alvarenga Cardoso Medeiros, Denise Utsch Gonçalves, Manoel Otávio da Costa Rocha and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Isabela de Andrade Ferraz *Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Ana Maria Ravena Severino Carvalho *Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Rory Cristiane Fortes de BritoNúcleo de Pesquisas Em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Bruno Mendes RoattNúcleo de Pesquisas Em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Vívian Tamietti MartinsPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Daniela Pagliara LagePrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Luiza Dos Reis CruzLaboratório de Química Orgânica Sintética, Instituto de Química, Universidade de Campinas, Campinas, Brazil.
Fernanda Alvarenga Cardoso MedeirosPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Denise Utsch GonçalvesPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Manoel Otávio da Costa RochaPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Eduardo Antonio Ferraz CoelhoPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Tiago Antônio de Oliveira MendesDepartamento de Bioquímica E Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-000, Brazil.
Mariana Costa DuartePrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Daniel Menezes-SouzaPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil. dmsouza@ufmg.br.ORCID http://orcid.org/0000-0002-6804-4320
Universidade Federal de Minas Gerais · BRUniversidade Federal de Ouro Preto · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Viçosa · BR

Funding

CAPES 23038.004862/2015-74Conselho Nacional de Desenvolvimento Científico e Tecnológico 311426/2019-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 439365/2018-0
6 · The paper itself

Abstract

Tegumentary leishmaniasis (TL) is a disease of high severity and incidence in Brazil, and Leishmania braziliensis is its main etiological agent. The inefficiency of control measures, such as high toxicity and costs of current treatments and the lack of effective immunoprophylactic strategies, makes the development of vaccines indispensable and imminent. In this light, the present work developed a gene encoding multiple T-cell (CD4

Indexed as

LeishmaniasisLeishmaniasis VaccinesAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEpitopes, T-LymphocyteImmunoglobulin GInterleukin-10MiceMice, Inbred BALB CEpitopes, T-LymphocyteImmunoglobulin GInterleukin-10Leishmaniasis VaccinesChimeric proteinImmunoinformaticsLeishmania braziliensisT-cell epitope mappingTegumentary leishmaniasisVaccine

Identifiers

PMID35759035
PMCPMC9244519
OpenAlexW4283583799

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.