Evidence map›Paper›PMID 35759432›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Voltage-dependent Ca

Marino DiFranco, Stephen C Cannon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier KProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. CaHandbook of experimental pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marino DiFrancoDepartment of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Stephen C CannonDepartment of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-8428-3690
University of California, Los Angeles · US

Funding

Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic ParalysisR01AR063182 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI STEPHEN C. CANNON · 2012 to 2026
$6.0M
Pathophysiology of Myotonia and Periodic ParalysisR01AR078198 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANNON, STEPHEN C. · 2021 to 2025
$2.7M
Optogenetic control of skeletal muscle excitabilityR21AR067422 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DI FRANCO, MARINO, VERGARA, JULIO L · 2014 to 2015
$373k
Opto-Electrophysiological Method to Study Human Skeletal Muscle ChannelopathiesR21AR080282 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DI FRANCO, MARINO, SHIEH, PERRY · 2022 to 2023
$360k
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR063182HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR078198NIAMS NIH HHS R01 AR063182NIAMS NIH HHS R01 AR078198NIAMS NIH HHS R21 AR067422NIAMS NIH HHS R21 AR080282
6 · The paper itself

Abstract

Hypokalemic periodic paralysis (HypoPP) is a channelopathy of skeletal muscle caused by missense mutations in the voltage sensor domains (usually at an arginine of the S4 segment) of the Ca

Indexed as

Calcium Channels, L-TypeHypokalemic Periodic ParalysisNAV1.4 Voltage-Gated Sodium ChannelAnimalsDisease Models, AnimalExcitation Contraction CouplingMiceMuscle, SkeletalMutation, MissenseCACNA1S protein, mouseCalcium Channels, L-TypeNAV1.4 Voltage-Gated Sodium ChannelScn4a protein, mousecalcium channelcalcium releasemouseskeletal musclesodium channel

Identifiers

PMID35759432
PMCPMC9359662
OpenAlexW4283581230

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.