Evidence map›Paper›PMID 35759450›Full record

ArticlePhysiological genomics2022

MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1β deficiency.

Emily Parker, Bharati Mendhe, Ling Ruan, Brendan Marshall, Wenbo Zhi, Yutao Liu, Sadanand Fulzele, Yao Liang Tang, Meghan McGee-Lawrence, Tae Jin Lee and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 11 citations in OpenAlex.

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  6. PdgfrαGenes & diseases · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Emily ParkerDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
Bharati MendheDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
Ling RuanDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
Brendan MarshallEM/Histology Core Laboratory, Medical College of Georgia at Augusta University, Augusta, Georgia.
Wenbo ZhiCenter for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia.
Yutao LiuDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
Sadanand FulzeleDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
Yao Liang TangVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.ORCID 0000-0002-8372-1545
Meghan McGee-LawrenceDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
Tae Jin LeeCenter for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia.
Ashok SharmaCenter for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia.
Maribeth JohnsonDivision of Biostatistics and Data Science, Medical College of Georgia at Augusta University, Augusta, Georgia.
Jie ChenDivision of Biostatistics and Data Science, Medical College of Georgia at Augusta University, Augusta, Georgia.
Mark W HamrickDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.ORCID 0000-0003-2246-3121
Augusta University · US

Funding

THE LEPTIN-IGF1 AXIS IN MUSCULOSKELETAL AGINGP01AG036675 · NIA · AUGUSTA UNIVERSITY · PI CARLOS M. ISALES · 2011 to 2026
$31.5M
NIA NIH HHS P01 AG036675
6 · The paper itself

Abstract

Fibro-adipogenic progenitor cells (FAPs) are a population of stem cells in skeletal muscle that play multiple roles in muscle repair and regeneration through their complex secretome; however, it is not well understood how the FAP secretome is altered with muscle disuse atrophy. Previous work suggests that the inflammatory cytokine IL-1β is increased in FAPs with disuse and denervation. Inflammasome activation and IL-1β secretion are also known to stimulate the release of extracellular vesicles (EVs). Here, we examined the microRNA (miRNA) cargo of FAP-derived, platelet-derived growth factor receptor A (PDGFRα

Indexed as

Extracellular VesiclesMicroRNAsMuscular Disorders, AtrophicAnimalsInterleukin-1betaMiceMuscle, SkeletalReceptor, Platelet-Derived Growth Factor alphaStem CellsIL1B protein, mouseInterleukin-1betaMicroRNAsReceptor, Platelet-Derived Growth Factor alphalet-7 familymiR-124miR-181aPDGFRαsenescence

Identifiers

PMID35759450
PMCPMC9342138
OpenAlexW4283583333

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.