ReviewNature reviews. Neuroscience2022
Freezing revisited: coordinated autonomic and central optimization of threat coping.
Review in Nature reviews. Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 128 citations in OpenAlex.
- Nocturnal Risk Assessment and Its Association With Anxiety Symptoms.Psychophysiology · 2026Trial
- Electrocortical and Physiological Correlates of Memory and Attention During the Anticipation of Avoidable and Inevitable Threats.Psychophysiology · 2026Article
- Stretch-Induced Muscle Responses Under Threat Versus Safety.The European journal of neuroscience · 2026Article
- Inhibition of either the sympathetic or parasympathetic nervous system increases tonic immobility duration in laying hens.Poultry science · 2026Article
- Cardiac vagal activity during in-vivo threat exposure is associated with within-session inhibition of fear and avoidance.Translational psychiatry · 2026Article
- How Temporal Predictability of Threat and Action Preparation Affect Defensive Freezing Responses.Psychophysiology · 2026Article
- Article
- Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.Clinical neuropsychiatry · 2026Article
- Intraindividual Variability Matters for the Correspondence Between Subjective Arousal, Valence, and Physiological Responses.Psychophysiology · 2026Article
- Confidence in naturalistic decision making.Neuroscience of consciousness · 2026Article
- Artificial light at night suppresses the metabolic response of a coral reef fish to a virtual predator.Conservation physiology · 2026Article
- The heartbeat evoked potential and the prediction of functional seizure semiology.Brain communications · 2026Article
- Generalized Isometric Sustained Contraction During Apnea Combined with Relaxation for Anxiety: A First Evaluation.Clinical practice and epidemiology in mental health : CP & EMH · 2026Article
- Article
- The anterior paraventricular thalamus counteracts fear expression during retrieval through both amygdala and subiculum circuits.Communications biology · 2025Article
- Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders.Molecular psychiatry · 2025Article
- Influence of the HPA Axis on Anxiety-Related Processes: An RDoC Overview Considering Their Neural Correlates.Current psychiatry reports · 2025Review
- Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Veterinary sciences · 2025Article
- Studying the influence of single social interactions on approach and avoidance behavior: A multimodal investigation in immersive virtual reality.Behavior research methods · 2025Article
- A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals have sophisticated mechanisms for coping with danger. Freezing is a unique state that, upon threat detection, allows evidence to be gathered, response possibilities to be previsioned and preparations to be made for worst-case fight or flight. We propose that - rather than reflecting a passive fear state - the particular somatic and cognitive characteristics of freezing help to conceal overt responses, while optimizing sensory processing and action preparation. Critical for these functions are the neurotransmitters noradrenaline and acetylcholine, which modulate neural information processing and also control the sympathetic and parasympathetic branches of the autonomic nervous system. However, the interactions between autonomic systems and the brain during freezing, and the way in which they jointly coordinate responses, remain incompletely explored. We review the joint actions of these systems and offer a novel computational framework to describe their temporally harmonized integration. This reconceptualization of freezing has implications for its role in decision-making under threat and for psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.