Evidence map›Paper›PMID 35762773›Full record

ArticleTherapeutic advances in cardiovascular disease

Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial.

Stefan T Birkett, Jonathan Sinclair, Sally A Seed, Sean Pymer, Edward Caldow, Lee Ingle, Amy E Harwood, Anselm Egun

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04370327 (The Effects of Claudication Severity on Functional Outcomes in Patients With Intermittent Claudication), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04370327 naunknown statusnot on this map

The Effects of Claudication Severity on Functional Outcomes in Patients With Intermittent Claudication

TypeinterventionalSponsorUniversity of Central LancashireRan2021 to 2025Enrolled51ConditionsIntermittent ClaudicationArmsPain Free Exercise (PF), Moderate Claudication Pain Exercise (MOD-P), Maximal Claudication Pain Exercise (MAX-P)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefan T BirkettSchool of Sport and Health Sciences, University of Central Lancashire, Preston PR1 2HE, UK.ORCID https://orcid.org/0000-0003-0422-6843
Jonathan SinclairSchool of Sport and Health Sciences, University of Central Lancashire, Preston, UK.
Sally A SeedSchool of Sport and Health Sciences, University of Central Lancashire, Preston, UK.
Sean PymerAcademic Vascular Surgical Unit, Hull York Medical School, Hull, UK.
Edward CaldowSchool of Health and Society, University of Salford, Salford, UK.
Lee IngleDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
Amy E HarwoodCentre for Sport, Exercise and Life Sciences, Coventry University, Coventry, UK.
Anselm EgunLancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeripheral artery disease affects over 236 million people globally and the classic symptom is intermittent claudication (IC) which is associated with reduction in physical activity. The evidence that supervised exercise programmes (SEPs) improve pain-free and maximal walking distance is irrefutable. However, adherence rates are low with exercise-related pain cited as a contributing factor. National and international guidelines recommend exercising at a moderate to maximal level of claudication pain to improve walking ability; however, exercising pain-free or at mild claudication pain has been shown to achieve this outcome. There is limited evidence that compares the relative effects of exercise prescribed at different levels of claudication pain.

objectiveThe objective of this study is to directly compare the effects of exercise prescribed at three different levels of claudication pain on walking performance.

designThis study will be a single-centre randomised controlled trial.

methodsBased on an ANALYSIS: Outcome measures will be assessed at baseline, 12 and 24 weeks adopting an analysis of covariance (ANCOVA) to compare MWD across three time points. The primary outcome for the trial will be change in maximal treadmill walking distance at 12 and 24 weeks. REGISTRATION: Trial registration number: NCT04370327.

Indexed as

Exercise TherapyIntermittent ClaudicationPeripheral Arterial DiseaseHumansRandomized Controlled Trials as TopicWalkingpainperipheral artery diseasesupervised exercise programme

Identifiers

PMID35762773
PMCPMC9243571

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.