Evidence map›Paper›PMID 35764616›Full record

ArticleNature communications2022

Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery.

Marie-Christine Vaney, Mariano Dellarole, Stéphane Duquerroy, Iris Medits, Georgios Tsouchnikas, Alexander Rouvinski, Patrick England, Karin Stiasny, Franz X Heinz, Félix A Rey

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Application of Orthoflavivirus Pseudovirus Technology in Antiviral Research.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. pr-independent biogenesis of infectious mature Zika virus particles.bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Marie-Christine Vaney *Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Unité de Virologie Structurale, Paris, France.ORCID 0000-0002-9071-9988
Mariano Dellarole *Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Unité de Virologie Structurale, Paris, France.ORCID 0000-0001-8044-4717
Stéphane Duquerroy *Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Unité de Virologie Structurale, Paris, France.
Iris MeditsCenter for Virology, Medical University of Vienna, Vienna, Austria.
Georgios TsouchnikasCenter for Virology, Medical University of Vienna, Vienna, Austria.
Alexander RouvinskiInstitut Pasteur, Université Paris Cité, CNRS UMR 3569, Unité de Virologie Structurale, Paris, France.
Patrick EnglandInstitut Pasteur, Université Paris Cité, CNRS UMR 3528, Plateforme de Biophysique Moléculaire, Paris, France.ORCID 0000-0001-6410-5918
Karin StiasnyCenter for Virology, Medical University of Vienna, Vienna, Austria. karin.stiasny@meduniwien.ac.at.ORCID 0000-0002-1902-8674
Franz X HeinzCenter for Virology, Medical University of Vienna, Vienna, Austria. Franz.X.Heinz@meduniwien.ac.at.ORCID 0000-0002-7191-4331
Félix A ReyInstitut Pasteur, Université Paris Cité, CNRS UMR 3569, Unité de Virologie Structurale, Paris, France. felix.rey@pasteur.fr.ORCID 0000-0002-9953-7988
Centre National de la Recherche Scientifique · FRMedical University of Vienna · ATInstitute for Pharmaeconomic Research · AT

Funding

Austrian Science Fund FWF I 1378Wellcome TrustWellcome Trust UNS22082
6 · The paper itself

Abstract

The flavivirus envelope glycoproteins prM and E drive the assembly of icosahedral, spiky immature particles that bud across the membrane of the endoplasmic reticulum. Maturation into infectious virions in the trans-Golgi network involves an acid-pH-driven rearrangement into smooth particles made of (prM/E)

Indexed as

Encephalitis Viruses, Tick-BorneFurinMembrane FusionViral Envelope ProteinsVirionFurinViral Envelope Proteins

Identifiers

PMID35764616
PMCPMC9239988
OpenAlexW4283652866

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.