Evidence map›Paper›PMID 35766032›Full record

ArticlePhysical chemistry chemical physics : PCCP2022

Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of

Silvia Gervasoni, Giuliano Malloci, Andrea Bosin, Attilio V Vargiu, Helen I Zgurskaya, Paolo Ruggerone

Open access · hybridAbstract read
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Proportions ofOpen forum infectious diseases · 2024
    Article
  10. The Art of War withAntibiotics (Basel, Switzerland) · 2023
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Silvia GervasoniDepartment of Physics, University of Cagliari, Citt. Universitaria, I-09042 Monserrato (Cagliari), Italy. giuliano.malloci@dsf.unica.it.ORCID http://orcid.org/0000-0002-5731-3396
Giuliano MallociDepartment of Physics, University of Cagliari, Citt. Universitaria, I-09042 Monserrato (Cagliari), Italy. giuliano.malloci@dsf.unica.it.ORCID http://orcid.org/0000-0002-5985-257X
Andrea BosinDepartment of Physics, University of Cagliari, Citt. Universitaria, I-09042 Monserrato (Cagliari), Italy. giuliano.malloci@dsf.unica.it.ORCID http://orcid.org/0000-0001-6300-5712
Attilio V VargiuDepartment of Physics, University of Cagliari, Citt. Universitaria, I-09042 Monserrato (Cagliari), Italy. giuliano.malloci@dsf.unica.it.ORCID http://orcid.org/0000-0003-4013-8867
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73072, USA.ORCID http://orcid.org/0000-0001-8929-4727
Paolo RuggeroneDepartment of Physics, University of Cagliari, Citt. Universitaria, I-09042 Monserrato (Cagliari), Italy. giuliano.malloci@dsf.unica.it.ORCID http://orcid.org/0000-0003-0825-0824
University of Cagliari · ITUniversity of Oklahoma · US

Funding

Optimization of efflux avoidance and inhibition for antibiotic developmentR01AI136799 · NIAID · UNIVERSITY OF OKLAHOMA · PI GNANAKARAN, SANDRASEGARAM, RUGGERONE, PAOLO · 2018 to 2022
$5.7M
NIAID NIH HHS R01 AI136799
6 · The paper itself

Abstract

The drug/proton antiporter MexB is the engine of the major efflux pump MexAB-OprM in

Indexed as

Escherichia coli ProteinsQuinolonesAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial Outer Membrane ProteinsEscherichia coliMembrane Transport ProteinsMicrobial Sensitivity TestsPseudomonas aeruginosaAcrB protein, E coliAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial Outer Membrane ProteinsEscherichia coli ProteinsMembrane Transport ProteinsQuinolones

Identifiers

PMID35766032
PMCPMC9278589
OpenAlexW4283730737

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.