ArticleNature2022
GREM1 is required to maintain cellular heterogeneity in pancreatic cancer.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 82 citations in OpenAlex.
- Pancreatic Cancer-Advances in the Last 50 Years.World journal of surgery · 2026Review
- Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target.Hepatology (Baltimore, Md.) · 2026Article
- C/EBP alpha agonist ICCB280 overcomes doxorubicin resistance in osteosarcoma through mitochondrial dynamics-dependent GREM1-MAPK activation.Cell death & disease · 2026Article
- Constructing a protein-protein interaction network for autoimmune liver diseases by integrating pQTL, rQTL, and mediation analyses.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Epithelial-to-mesenchymal transition as a central driver of tumor cell plasticity.Nature cancer · 2026Review
- Adipogenic transdifferentiation reprograms EMT-high PDAC cells into a post-mitotic adipocyte-like state and limits metastasis.Cell death & disease · 2026Article
- A paracrine-to-autocrine shunt of GREM1 fuels colorectal cancer metastasis via ACVR1C.Molecular cancer · 2026Article
- Multi-omics and experimental validation identify USP54 as a prognostic deubiquitinase promoting pancreatic ductal adenocarcinoma progression within the immune microenvironment.Frontiers in immunology · 2026Article
- Vortioxetine enhances the anti-pancreatic cancer efficacy of gemcitabine through reducing MAOB expression.Frontiers in pharmacology · 2026Article
- Fibroblast-derived gremlin-1 Is associated with ovarian cancer-cell phenotypes in co-culture models.Frontiers in oncology · 2026Article
- Dihydroalterperylenol from endophytic fungusMolecular medicine reports · 2026Article
- Article
- Review
- Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity.Nature · 2025Article
- Article
- GREM1 deficiency induced bone marrow adipose niche promotes B-cell acute lymphoblastic leukemia disease progression.International journal of cancer · 2025Article
- Article
- Noggin Promotes Cell Proliferation Through Up-regulating EGFR/HER2 in Pancreatic Cancer Cells.Cancer genomics & proteomics · 2025Article
- Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.Nature communications · 2025Article
- Shaping epithelial tissues by stem cell mechanics in development and cancer.Nature reviews. Molecular cell biology · 2025Review
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 3 countries.
Linxiang LanCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-8409-4336
Theodore Evan *Cancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Huafu Li *Cancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Aasia HussainSystems and Precision Cancer Medicine Laboratory, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, UK.
E Josue RuizCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
May Zaw ThinCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0003-0036-2776
Rute M M FerreiraTumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.
Hari PsSystems and Precision Cancer Medicine Laboratory, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, UK.
Eva M RiisingSamplix ApS, Birkerød, Denmark.
Yoh ZenInstitute of Liver Studies, King's College Hospital, London, UK.
Jorge AlmagroCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-0652-6447
Kevin W NgRetroviral Immunology Laboratory, The Francis Crick Institute, London, UK.
Pablo Soro-BarrioThe Bioinformatics & Biostatistics STP, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-4509-6109
Jessica NelsonCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Gabriela KoifmanCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Joana CarvalhoThe Experimental Histopathology STP, The Francis Crick Institute, London, UK.
Emma L NyeThe Experimental Histopathology STP, The Francis Crick Institute, London, UK.
Yulong HeDigestive Medicine Centre, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
Changhua ZhangDigestive Medicine Centre, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
Anguraj SadanandamSystems and Precision Cancer Medicine Laboratory, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, UK.ORCID http://orcid.org/0000-0001-8485-5150
Axel BehrensCancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. Axel.Behrens@icr.ac.uk.ORCID http://orcid.org/0000-0002-1557-1143
Institute of Cancer Research · GBThe Francis Crick Institute · GBSun Yat-sen University · CNBreast Cancer Now · GBChampalimaud Foundation · PTKing's College Hospital · GB
Funding
Wellcome Trust FC001039Wellcome Trust FC001317
Abstract
Pancreatic ductal adenocarcinoma (PDAC) shows pronounced epithelial and mesenchymal cancer cell populations
Indexed as
Epithelial-Mesenchymal TransitionIntercellular Signaling Peptides and ProteinsPancreatic NeoplasmsAnimalsCarcinoma, Pancreatic DuctalCell Line, TumorCytokinesEpithelial CellsHumansMesodermMiceSnail Family Transcription FactorsCytokinesGREM1 protein, humanGrem1 protein, mouseIntercellular Signaling Peptides and ProteinsSnai1 protein, mouseSnai2 protein, mouseSnail Family Transcription Factors
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.