Evidence map›Paper›PMID 35768997›Full record

ArticleCell proliferation2022

Peripubertal requirement of Tsg101 in maintaining the integrity of membranous structures in mouse oocytes.

Hyejin Shin, Dayoung Park, Jiyeon Kim, Min-Yeong Nam, Sojung Kwon, Da-Eun Um, Ji-Eun Oh, Esther Youn, Yhong-Hee Shim, Kay-Uwe Wagner and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Hyejin ShinDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Dayoung ParkDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Jiyeon KimDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Min-Yeong NamDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Sojung KwonDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Da-Eun UmDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Ji-Eun OhDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Esther YounDepartment of Bioscience and Biotechnology, Konkuk University, Seoul, Republic of Korea.
Yhong-Hee ShimDepartment of Bioscience and Biotechnology, Konkuk University, Seoul, Republic of Korea.
Kay-Uwe WagnerWayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.
Jin Hyun JunDepartment of Biomedical Laboratory Science, Eulji University, Seongnam, Gyeonggi-do, Republic of Korea.
Hye-Ryun KimDepartment of Biomedical Science, CHA University, Seongnam, Gyeonggi-do, Republic of Korea.
Haengseok SongDepartment of Biomedical Science, CHA University, Seongnam, Gyeonggi-do, Republic of Korea.
Hyunjung Jade LimDepartment of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-2191-666X
Konkuk University · KRCHA University · KREulji University · KRWayne State University · US

Funding

Targeting the PTAP Domain of TSG101 in ERBB2-associated Mammary CancerR03CA219332 · NCI · WAYNE STATE UNIVERSITY · PI WAGNER, KAY-UWE · 2017 to 2018
$153k
National Research Foundation of Korea 2018R1D1A1B07045205National Research Foundation of Korea 2019R1A6A1A03032888National Research Foundation of Korea 2020R1A2C1004122NCI NIH HHS R03 CA219332U.S. Public Health Service CA219332
6 · The paper itself

Abstract

objectiveAs a component of Endosomal Sorting Complex Required for Transport (ESCRT) complex I, the tumor susceptibility gene 101 (Tsg101) carries out multiple functions. In this work, we report that oocyte-specific deletion of tumor susceptibility gene 101 (Tsg101) leads to age-dependent oocyte demise in mice. MATERIALS AND

methodTsg101 floxed mice (Tsg101

resultsThe death of oocytes from Zp3

conclusionsCollectively, Tsg101 plays a dual role in maintaining the integrity of membranous structures, which is influenced by age in mouse oocytes.

Indexed as

Endosomal Sorting Complexes Required for TransportOocytesAnimalsDNA-Binding ProteinsGonadotropin-Releasing HormoneMiceMice, TransgenicTranscription FactorsTsg101 ProteinDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportGonadotropin-Releasing HormoneTranscription FactorsTsg101 Protein

Identifiers

PMID35768997
PMCPMC9528763
OpenAlexW4283720206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.