ArticleFrontiers in endocrinology2022
Association Between Serum Uric Acid Level and Carotid Atherosclerosis and Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the efficacy and safety of benzbromarone and febuxostat in gout and hyperuricemia: a systematic review and meta-analysis.Clinical rheumatology · 2024Pooled it
- Type 2 diabetes mellitus and incident carotid atherosclerosis: a retrospective cohort study on composite indices.Frontiers in endocrinology · 2026Article
- Early predictors of carotid atherosclerosis in patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- Comprehensive analysis of risk factors associated with carotid plaque in patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- The dose-response relationship and gender differences of serum uric acid with total cholesterol: a cross-sectional study.The Journal of international medical research · 2025Article
- Predictive value of uric acid to albumin ratio for carotid atherosclerosis in type 2 diabetes mellitus: A retrospective study.PloS one · 2025Article
- Development and Validation of a Nomogram for Predicting Hyperuricemia in Perimenopausal Women.International journal of general medicine · 2025Article
- Assessment of urate-lowering therapies on lipid metabolism and kidney function in non-dialysis chronic kidney disease patients: 12 months multicenter cohort study.Frontiers in endocrinology · 2025Observational
- Comprehensive analysis of risk factors and metabolic profiling in preclinical atherosclerosis: a cross-sectional study.Frontiers in physiology · 2025Article
- Correlations of serum uric acid, fibrinogen and homocysteine levels with carotid atherosclerosis in hypertensive patients.Frontiers in cardiovascular medicine · 2025Article
- Predictive value of the serum uric acid to high-density lipoprotein cholesterol ratio for culprit plaques in patients with acute coronary syndrome.BMC cardiovascular disorders · 2024Article
- Associations of blood biomarkers with arterial stiffness in patients with diabetes mellitus: A population-based study.Journal of diabetes · 2023Article
- A predictive model for hyperuricemia among type 2 diabetes mellitus patients in Urumqi, China.BMC public health · 2023Article
- Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China.Diabetology & metabolic syndrome · 2023Article
- Sex-specific association of serum uric acid trajectories with risk of incident retinal arteriosclerosis in Chinese population: A population-based longitudinal study.Frontiers in cardiovascular medicine · 2023Article
- Association between hyperuricemia and metabolic syndrome: A cross-sectional study in Tibetan adults on the Tibetan plateau.Frontiers in endocrinology · 2022Article
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9 authors.
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Abstract
Background: Serum uric acid (SUA) is associated with many cardiovascular risk factors, such as metabolic syndrome (MetS) and subclinical atherosclerosis. However, the relationship of SUA with carotid atherosclerosis remains controversial. We aimed to investigate whether elevated SUA levels are associated with a high risk of carotid atherosclerosis and MetS in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness and carotid artery plaques were measured Results: Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54-5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis. Conclusions: In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.
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