Evidence map›Paper›PMID 35770043›Full record

ArticleOxidative medicine and cellular longevity2022

Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1

Zhuo-Na Han, Xiao-Xue Lin, Yue-Ying Wang, Ran Ding, Lan Hong, Xun Cui

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Future GLP-1 receptor co-agonists and their cardiac effects.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Research (Washington, D.C.) · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhuo-Na HanDepartment of Physiology, School of Medical Sciences, Yanbian University, Yanji 133-002, China.
Xiao-Xue LinDepartment of Physiology, School of Medical Sciences, Yanbian University, Yanji 133-002, China.
Yue-Ying WangDepartment of Physiology, School of Medical Sciences, Yanbian University, Yanji 133-002, China.
Ran DingDepartment of Physiology, School of Medical Sciences, Yanbian University, Yanji 133-002, China.
Lan HongDepartment of Physiology, School of Medical Sciences, Yanbian University, Yanji 133-002, China.ORCID https://orcid.org/0000-0003-1010-6039
Xun CuiDepartment of Physiology, School of Medical Sciences, Yanbian University, Yanji 133-002, China.ORCID https://orcid.org/0000-0002-1680-6354
Yanbian University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial natriuretic peptide (ANP), a canonical cardiac hormone, is mainly secreted from atrial myocytes and is involved in the regulation of body fluid, blood pressure homeostasis, and antioxidants. Cholecystokinin (CCK) is also found in cardiomyocytes as a novel cardiac hormone and induces multiple cardiovascular regulations. However, the direct role of CCK on the atrial mechanical dynamics and ANP secretion is unclear. The current study was to investigate the effect of CCK octapeptide (CCK-8) on the regulation of atrial dynamics and ANP secretion. Experiments were performed in isolated perfused beating rat atria. ANP was measured using radioimmunoassay. The levels of hydrogen peroxide (H

Indexed as

Atrial Natriuretic FactorPPAR gammaAnimalsHeart AtriaHydrogen PeroxideNADPH Oxidase 4PPAR alphaRatsSincalideSuperoxide DismutaseAtrial Natriuretic FactorHydrogen PeroxideNADPH Oxidase 4Nox4 protein, ratPPAR alphaPPAR gammaSincalideSuperoxide Dismutase

Identifiers

PMID35770043
PMCPMC9236793
OpenAlexW4283217575

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.