Evidence map›Paper›PMID 35772473›Full record

ReviewDevelopmental biology2022

When is a neuron like an epithelial cell.

Maxwell G Heiman

Abstract readReview
In one paragraph

Review in Developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Enteric Nervous System: Identification of a Novel Neuronal Sensory Network in the Duodenal Epithelium.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Maxwell G HeimanDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, 02115, USA. Electronic address: heiman@genetics.med.harvard.edu.

Funding

Development of Specific Neuron-Glia AttachmentsR01NS112343 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Maxwell Heiman · 2019 to 2026
$3.3M
NINDS NIH HHS R01 NS112343
6 · The paper itself

Abstract

Neurons and epithelia are viewed as fundamentally different cell types, yet some sensory neurons exhibit hallmarks of epithelial cells. For example, they use tight junctions to form a diffusion barrier continuous with the skin or other epithelia and they exhibit bona fide apical-basal polarity, with an outward-facing apical surface that is biochemically and functionally distinct from their inward-facing basolateral surface. Yet they are unmistakeably neurons with axon-dendrite polarity. Examples include olfactory receptor neurons and photoreceptors. In this review, I highlight how viewing these neurons as specialized epithelial cells informs our understanding of their development and raises intriguing questions about the establishment of apical-basal and axon-dendrite polarity.

Indexed as

Cell PolarityEpithelial CellsEpitheliumNeuronsTight Junctions

Identifiers

PMID35772473
PMCPMC9378717

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.