Evidence map›Paper›PMID 35772752›Full record

ReviewJournal of animal science2022

Ruminant conceptus-maternal interactions: interferon-tau and beyond.

Daniel J Mathew, Katie D Peterson, L Kirsten Senn, Mary A Oliver, Alan D Ealy

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of animal science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  9. Review
  10. Bovine Endometrium Drives and Responds to Divergence of In Vitro Produced Conceptus Biochemistry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel J MathewDepartment of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0002-7351-3865
Katie D PetersonDepartment of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
L Kirsten SennDepartment of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
Mary A OliverDepartment of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Alan D EalyDepartment of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0002-8507-6578
University of Tennessee at Knoxville · USVirginia Tech · US

Funding

Agriculture and Food Research Initiative Competitive 2020-67015-31617
6 · The paper itself

Abstract

Embryonic or fetal loss in cattle is associated with problems that occur during oocyte maturation, early embryonic development, conceptus elongation, maternal recognition of pregnancy (MRP), and/or placental attachment and implantation. Many of these problems manifest as inadequate or asynchronous communication between the developing conceptus and endometrium, resulting in pregnancy failure. This review will provide an overview of how various conceptus-endometrial paracrine signaling systems control the fate of early pregnancy in cattle and other ruminants. We begin by summarizing the actions of interferon-tau, the classic MRP signal in ruminates, and then explore how other secretory factors derived from either the conceptus or endometrium influence establishment and maintenance of pregnancy. Insight into how the endometrium responds to male vs. female conceptuses or conceptuses produced by in vitro methods will also be described. Specific focus will be placed on describing how "omic" technologies and other cutting-edge techniques have assisted with identifying novel conceptus and/or endometrial factors and their functions. Recent findings indicate that the endometrial transcriptome and histotroph are altered by conceptus sex, quality, and origin, suggesting that the endometrium is a sensor of conceptus biochemistry. Although the endometrium has a certain level of flexibility in terms of conceptus-maternal interactions, this interplay is not sufficient to retain some pregnancies. However, new information inspires us to learn more and will help develop technologies that mitigate early embryonic loss and reproductive failure in ruminants and other animals.

Indexed as

Embryo ImplantationPregnancy, AnimalAnimalsCattleEndometriumFemaleInterferon Type IMalePlacentaPregnancyPregnancy ProteinsRuminantsinterferon tauInterferon Type IPregnancy Proteinsbovineembryoendometriumovinepregnancytranscriptomics

Identifiers

PMID35772752
PMCPMC9246669
OpenAlexW4283759040

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.