Evidence map›Paper›PMID 35774233›Full record

ArticleNAR cancer2022

POLQ suppresses genome instability and alterations in DNA repeat tract lengths.

Kate Liddiard, Alys N Aston-Evans, Kez Cleal, Eric A Hendrickson, Duncan M Baird

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026
    Review
  4. Article
  5. Multifaceted Nature of DNA Polymerase θ.International journal of molecular sciences · 2023
    Review
  6. Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kate LiddiardDivision of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID https://orcid.org/0000-0002-0953-1997
Alys N Aston-EvansDementia Research Institute, School of Medicine, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK.
Kez ClealDivision of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID https://orcid.org/0000-0002-9775-3476
Eric A HendricksonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0000-0001-6734-6426
Duncan M BairdDivision of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID https://orcid.org/0000-0001-8408-5467
Cardiff University · GBUK Dementia Research Institute · GBUniversity of Minnesota Medical Center · US

Funding

POLQ- and CtIP-regulated telomere fusions and translocations are involved in early events in carcinogenesisR01CA266524 · NCI · UNIVERSITY OF VIRGINIA · PI HENDRICKSON, ERIC A · 2022 to 2025
$2.5M
Cancer Research UK 29202NCI NIH HHS R01 CA266524
6 · The paper itself

Abstract

DNA polymerase theta (POLQ) is a principal component of the alternative non-homologous end-joining (ANHEJ) DNA repair pathway that ligates DNA double-strand breaks. Utilizing independent models of POLQ insufficiency during telomere-driven crisis, we found that

Identifiers

PMID35774233
PMCPMC9241439
OpenAlexW4283781589

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.