ArticlePlant physiology2022
How abiotic stress-induced socialization leads to the formation of massive aggregates in Chlamydomonas.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Simple Electroporation ofBio-protocol · 2026Article
- Material-Dependent Toxic Mechanisms of Different Types of Particulate Emerging Contaminants TowardToxics · 2026Article
- Induction of collective behavior by β-1,3-glucans in microalgae.Science advances · 2026Article
- Field strains of the unicellular alga Chlamydomonas reinhardtii exhibit multicellular characteristics that shape their interactions.The ISME journal · 2026Article
- Reactive oxygen species trigger downward vertical migration in diatom microphytobenthic biofilms as a strategy to cope with oxidative stress.The ISME journal · 2026Article
- A close unicellular relative reveals aggregative multicellularity was key to the evolution of animals.bioRxiv : the preprint server for biology · 2025Article
- The DYRKP1 kinase regulates cell wall degradation in Chlamydomonas by inducing matrix metalloproteinase expression.The Plant cell · 2024Article
- The MicroalgaeCells · 2024Review
- A recipe for death: Singlet oxygen and type II metacaspase mediate programmed cell death in Chlamydomonas.Plant physiology · 2024Article
- Type II metacaspase mediates light-dependent programmed cell death in Chlamydomonas reinhardtii.Plant physiology · 2024Article
- Single-cell adaptations shape evolutionary transitions to multicellularity in green algae.Nature ecology & evolution · 2023Article
- Palmelloid Formation and Cell Aggregation Are Essential Mechanisms for High Light Tolerance in a Natural Strain ofInternational journal of molecular sciences · 2023Article
- Stronger together: How unicellular algae respond to stress by socialization.Plant physiology · 2022Article
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8 authors.
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Abstract
Multicellular organisms implement a set of reactions involving signaling and cooperation between different types of cells. Unicellular organisms, on the other hand, activate defense systems that involve collective behaviors between individual organisms. In the unicellular model alga Chlamydomonas (Chlamydomonas reinhardtii), the existence and the function of collective behaviors mechanisms in response to stress remain mostly at the level of the formation of small structures called palmelloids. Here, we report the characterization of a mechanism of abiotic stress response that Chlamydomonas can trigger to form massive multicellular structures. We showed that these aggregates constitute an effective bulwark within which the cells are efficiently protected from the toxic environment. We generated a family of mutants that aggregate spontaneously, the socializer (saz) mutants, of which saz1 is described here in detail. We took advantage of the saz mutants to implement a large-scale multiomics approach that allowed us to show that aggregation is not the result of passive agglutination, but rather genetic reprogramming and substantial modification of the secretome. The reverse genetic analysis we conducted allowed us to identify positive and negative regulators of aggregation and to make hypotheses on how this process is controlled in Chlamydomonas.
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