Evidence map›Paper›PMID 35776282›Full record

ArticleClinical rheumatology2022

Increased epicardial adipose tissue thickness correlates with endothelial dysfunction in spondyloarthritis.

Aicha Ben Tekaya, Takwa Mehmli, Imtinene Ben Mrad, Ahmed Fendri, Seif Boukriba, Selma Bouden, Leila Rouached, Rawdha Tekaya, Olfa Saidane, Ines Mahmoud and 1 more

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Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Aicha Ben TekayaRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Takwa MehmliRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia. mehmlitakwa@gmail.com.ORCID http://orcid.org/0000-0003-2320-5300
Imtinene Ben MradFaculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
Ahmed FendriFaculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
Seif BoukribaFaculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
Selma BoudenRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Leila RouachedRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Rawdha TekayaRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Olfa SaidaneRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Ines MahmoudRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Leila AbdelmoulaRheumatology Department, Charles Nicolle Hospital, Tunis, 1007, Tunisia.
Tunis University · TNHôpital Charles-Nicolle · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe aimed to investigate the relationship between epicardial adipose tissue (EAT) thickness, flow-mediated dilation (FMD), and carotid intima-media thickness (cIMT) in spondyloarthritis (SpA) patients compared to healthy controls.

methodsWe performed a cross-sectional study including SpA patients aged ≤ 50 years without traditional cardiovascular risk factors and healthy controls matched for age and gender. Baseline characteristics, laboratory data, and SpA-related parameters were recorded. All participants underwent ultrasound examination with measurement of EAT thickness, FMD, and cIMT by both an experienced cardiologist and radiologist blinded to clinical data. The relationships between the ultrasound measurements were analyzed using Spearman's correlation coefficient and Person correlation.

resultsThe study included 94 subjects (47 SpA and 47 healthy controls). The sex-ratio was 2.35; the median age of patients was 36 years (IQR: 28-46), and the median disease duration was 11 years (IQR: 5-16). Compared to the control group, SpA patients had significantly higher values of EAT thickness (p = 0.001) and cIMT (p < 0.0001). FMD values were significantly lower in SpA patients compared to controls (p = 0.008). The univariate analysis detected a significant negative association between EAT thickness and FMD (p = 0.026; r =  - 0.325), and between left cIMT and FMD (p = 0.027; r =  - 0.322). No association was found between EAT thickness and cIMT.

conclusionEAT thickness, FMD, and cIMT were significantly impaired in SpA patients compared with healthy controls supporting evidence of accelerated atherosclerosis in SpA. EAT thickness was correlated to endothelial dysfunction suggesting the role of EAT in predicting the early reversible stages of atherosclerosis. Key Points • Spondyloarthritis is associated with impaired subclinical atherosclerosis markers accurately increased epicardial fat and carotid intima-media thickness and endothelial dysfunction. • Increased epicardial fat thickness is correlated with impaired endothelial function in spondyloarthritis patients.

Indexed as

AtherosclerosisSpondylarthritisAdipose TissueAdultCarotid Intima-Media ThicknessCross-Sectional StudiesHumansMiddle AgedPericardiumRisk FactorsAtherosclerosisCarotid intima-media thicknessEpicardial adipose tissueFlow-mediated dilationSpondyloarthritis

Identifiers

PMID35776282
OpenAlexW4283748832

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.