Evidence map›Paper›PMID 35776514›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

Oanh N Hoang, Anna Ermund, Ana M Jaramillo, Dalia Fakih, Cory B French, Jose R Flores, Harry Karmouty-Quintana, Jesper M Magnusson, Giorgio Fois, Michael Fauler and 11 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Airway secretory cells contain both a perinuclear Golgi ribbon and dispersed Golgi satellites.American journal of respiratory cell and molecular biology · 2026
    Article
  3. Article
  4. Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  5. Article
  6. Article
  7. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Cystic fibrosis.Nature reviews. Disease primers · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Mucus aberrant properties in CF: Insights from cells and animal models.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Review
  18. Mucins MUC5AC and MUC5B in the Airways: MUCing around Together.American journal of respiratory and critical care medicine · 2022
    Article
  19. Regulated Restructuring of Mucins During Secretory Granule Maturation In Vivo.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 3 countries.

Oanh N HoangDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-5304-585X
Anna ErmundDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-3233-043X
Ana M JaramilloDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-8089-4275
Dalia FakihDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Cory B FrenchWashington University School of Medicine, St. Louis, Missouri.ORCID 0000-0003-1655-3614
Jose R FloresWashington University School of Medicine, St. Louis, Missouri.ORCID 0000-0003-2942-6147
Harry Karmouty-QuintanaDivision of Critical Care, Pulmonary, and Sleep Medicine, Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0003-4753-9823
Jesper M MagnussonDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-5630-0155
Giorgio FoisInstitute of General Physiology, Ulm University, Ulm, Germany.ORCID 0000-0001-5414-1149
Michael FaulerInstitute of General Physiology, Ulm University, Ulm, Germany.ORCID 0000-0002-7371-849X
Manfred FrickInstitute of General Physiology, Ulm University, Ulm, Germany.ORCID 0000-0002-4763-1104
Peter BraubachHannover Medical School Hospital, Hannover, Germany.ORCID 0000-0003-3673-7779
Joshua B HalesWashington University School of Medicine, St. Louis, Missouri.ORCID 0000-0003-1122-3990
Richard C KurtenUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas.
Reynold PanettieriRutgers New Jersey Medical School, New Brunswick, New Jersey.ORCID 0000-0003-0834-4636
Leoncio VergaraInstitute of Biosciences and Technology, Texas A&M School of Medicine, Houston, Texas; and.ORCID 0000-0001-7427-9567
Camille EhreMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-0046-0096
Roberto AdachiDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-0146-0768
Michael J TuvimDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-8126-7716
Gunnar C HanssonDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-1900-1869
Burton F DickeyDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-4780-1847
The University of Texas MD Anderson Cancer Center · USUniversity of Gothenburg · SEUniversität Ulm · DEWashington University in St. Louis · USMedizinische Hochschule Hannover · DERutgers, The State University of New Jersey · USTexas A&M Health Science Center · USThe University of Texas Health Science Center at Houston · USUniversity of Arkansas for Medical Sciences · USUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Controlling the core airway mucin secretion machinery to prevent pathophysiologyR01HL129795 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DICKEY, BURTON F · 2015 to 2023
$3.8M
Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary FibrosisR01HL157100 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2021 to 2025
$2.8M
The MUC2 Mucus Gel as an Innate Immune Mechanism that Inhibits InflammationU01AI095473 · NIAID · GOTEBORG UNIVERSITY · PI HANSSON, GUNNAR C., JOHANSSON, MALIN E.V. · 2011 to 2020
$2.6M
3'UTR Shortening In Pulmonary Vascular DiseaseR01HL138510 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2017 to 2021
$2.3M
NCATS NIH HHS UL1 TR003017NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA016672NHLBI NIH HHS R01 HL129795NHLBI NIH HHS R01 HL138510NHLBI NIH HHS R01 HL157100NHLBI NIH HHS UL1TR003017NIAID NIH HHS U01 AI095473NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mucin-5BPulmonary Disease, Chronic ObstructiveAnimalsHumansLungMammalsMiceMucin 5ACSecretory VesiclesSwineMUC5AC protein, humanMuc5ac protein, mouseMUC5B protein, humanMuc5b protein, mouseMucin 5ACMucin-5Bairway mucinsclub cellsMUC5ACMUC5Bmucus

Identifiers

PMID35776514
PMCPMC9704839
OpenAlexW4283765516

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.