ArticleQuantitative imaging in medicine and surgery2022
Aneurysmal wall enhancement and hemodynamics: pixel-level correlation between spatial distribution.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- Local pressure as a dominant hemodynamic driver of wall enhancement in anterior communicating artery aneurysms: a facet-level computational fluid dynamics and vessel wall imaging analysis.Quantitative imaging in medicine and surgery · 2026Article
- Letter to the Editor: Correlation between computational fluid dynamics-derived low wall shear stress and vessel wall enhancement on high-resolution MR vessel wall imaging in intracranial aneurysms.European radiology · 2026Article
- Reply to the Letter to the Editor: Correlation between computational fluid dynamics-derived low wall shear stress and vessel wall enhancement on high-resolution MR vessel wall imaging in intracranial aneurysms.European radiology · 2026Article
- Separate aneurysmal neck is essential for analyzing hemodynamics and predicting instability of intracranial aneurysms.Annals of medicine · 2025Article
- Dual-volume reconstruction technology in the detection and classification of recurrent aneurysms following intracranial aneurysm embolization.Quantitative imaging in medicine and surgery · 2025Article
- Correlations between hemodynamics and radiomic features in thrombosed intracranial aneurysms.Neuroradiology · 2025Article
- Differential hemodynamics between autogenous arteriovenous fistulas in forearm created by modified no-touch technique and conventional surgery: four-dimensional flow magnetic resonance imaging approach.Quantitative imaging in medicine and surgery · 2025Article
- Hemodynamic relationship with angioarchitecture of cerebral arteriovenous malformation and changes after embolization: a pilot study by 4D flow MR.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Hemodynamic assessments of unilateral pulsatile tinnitus with jugular bulb wall dehiscence using 4D flow magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Systemic immune-inflammation index is associated with aneurysmal wall enhancement in unruptured intracranial fusiform aneurysms.Frontiers in immunology · 2023Article
- Three-dimensional aneurysm wall enhancement in fusiform intracranial aneurysms is associated with aneurysmal symptoms.Frontiers in neuroscience · 2023Article
- Aneurysm wall enhancement, hemodynamics, and morphology of intracranial fusiform aneurysms.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammation and hemodynamics are interrelated risk factors for intracranial aneurysm rupture. This study aimed to identify the relationship between these risk factors from an individual-patient perspective using biomarkers of aneurysm wall enhancement (AWE) derived from high-resolution magnetic resonance imaging (HR-MRI) and hemodynamic parameters by four-dimensional flow MRI (4D-flow MRI). Methods: A total of 29 patients with 29 unruptured intracranial aneurysms larger than 4 mm were included in this prospective cross-sectional study. A total of 24 aneurysms had AWE and 5 did not have AWE. A three-dimensional (3D) vessel model of each individual aneurysm was generated with 3D time-of-flight magnetic resonance angiography (3D TOF-MRA). Quantification of AWE was sampled with HR-MRI. Time-averaged wall shear stress (WSS) and oscillatory shear index (OSI) were calculated from the 4D-flow MRI. The correlation between spatial distribution of AWE and hemodynamic parameters measured at pixel-level was evaluated for each aneurysm. Results: In aneurysms with AWE, the spatial distribution of WSS was negatively correlated with AWE in 100% (24/24) of aneurysms, though 2 had an absolute value of the correlation coefficient <0.1. The OSI was positively correlated with AWE in 91.7% (22/24) of aneurysms; the other 2 aneurysms showed a negative correlation with AWE. In aneurysms with no AWE, there was no correlation between WSS (100%, 5/5), OSI (80%, 4/5), and wall inflammation. Conclusions: The spatial distribution of WSS was negatively correlated with AWE in aneurysms with AWE, and OSI was positively correlated with AWE in most aneurysms with AWE. While aneurysms that did not contain AWE showed no correlation between hemodynamics and wall inflammation.
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