Evidence map›Paper›PMID 35782450›Full record

SynthesisFrontiers in psychiatry2022

Effect of Physical Exercise on Cognitive Function of Alzheimer's Disease Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.

Wei Liu, Jia Zhang, Yanyan Wang, Junfeng Li, Jindong Chang, Qingyin Jia

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06637228 (Effects of Integrated Exercise on Sarcopenia, Depression Symptoms, and Quality of Life of Community-Dwelling Older Adults With Dementia), which is not on this map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06637228 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Integrated Exercise on Sarcopenia, Depression Symptoms, and Quality of Life of Community-Dwelling Older Adults With Dementia

TypeinterventionalSponsorChang Gung University of Science and TechnologyRan2023 to 2024Enrolled80ConditionsDementia, Depressive Symptoms, Quality of Life (QOL), Sarcopenia in ElderlyArmsMove Your Hands, Feet, and Brain: Integrated Exercise Intervention Based on Taipei City Elderly Physical Activity Guidelines
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Effects of physical exercise on cognitive impairment in patients with Alzheimer's disease, Parkinson's disease or mild cognitive impairment: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Review
  9. Review
  10. Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Observational
  11. Review
  12. Review
  13. Review
  14. Review
  15. Biomarkers of cognitive and memory decline in psychotropic drug users.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei LiuSchool of Physical Education, Xuzhou Kindergarten Teachers College, Xuzhou, China.
Jia ZhangQingdao Mental Health Center, Qingdao University, Qingdao, China.
Yanyan WangQingdao Mental Health Center, Qingdao University, Qingdao, China.
Junfeng LiMinistry of Sports, Shandong Technology and Business University, Yantai, China.
Jindong ChangInstitute of Motor Quotient, Southwest University, Chongqing, China.
Qingyin JiaFinancial Department, Shandong Sports University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review aims to systematically review the effects of physical exercise on the cognitive performance of patients with Alzheimer's disease (AD) and its mechanisms of action. Databases such as Web of Science, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched until December 2021. A randomized controlled trial (RCT) to assess the effect of an exercise intervention (compared with no exercise) on patients with AD. The measures included cognitive function [Mini-Mental State Examination (MMSE), Alzheimer's Disease assessment scale-cognitive (ADAS-Cog), Montreal cognitive assessment scale (MoCA) and Executive Function (EF)]. The methodological quality of the included literature was assessed using the Physiotherapy Evidence Database (PEDro) scale. Twenty-two studies (

Indexed as

Alzheimer's diseasecognitionmeta-analysisphysical exercisesystematic review

Identifiers

PMID35782450
PMCPMC9243422

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.