Evidence map›Paper›PMID 35785481›Full record

ArticleObesity (Silver Spring, Md.)2022

Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans.

Jerod M Rasmussen, Paul M Thompson, Lauren E Gyllenhammer, Karen L Lindsay, Thomas G O'Connor, Berthold Koletzko, Sonja Entringer, Pathik D Wadhwa, Claudia Buss

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jerod M RasmussenDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, California, USA.ORCID 0000-0002-9400-7750
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lauren E GyllenhammerDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, California, USA.
Karen L LindsayDepartment of Pediatrics, University of California, Irvine, Irvine, California, USA.
Thomas G O'ConnorDepartments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-8590-5057
Berthold KoletzkoDivision of Metabolic and Nutritional Medicine, Department of Pediatrics, Dr von Hauner Children's Hospital, Ludwig-Maximillian University Munich, University Hospitals, Munich, Germany.
Sonja EntringerDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, California, USA.
Pathik D WadhwaDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, California, USA.
Claudia BussDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, California, USA.
University of California, Irvine · USLudwig-Maximilians-Universität München · DEUniversity of Rochester Medical Center · USUniversity of Southern California · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUH3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI Emily S Barrett, Richard Kermit Miller · 2018 to 2026
$15.9M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0M
Intergenerational Effects of Maternal Childhood Trauma on the Fetal BrainR01MH105538 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, FAIR, DAMIEN A · 2015 to 2019
$3.5M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Fetal Programming of Human Newborn Energy Homeostasis Brain NetworksR00HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2023 to 2025
$744k
Prenatal diet-stress interactions and the maternal metabolic response in human pregnancyR00HD096109 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI LINDSAY, KAREN · 2020 to 2022
$737k
Human Newborn Energy Homeostasis Brain Networks And Infant AdiposityR21DK118578 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, PAUL M, WADHWA, PATHIK D · 2019 to 2020
$351k
Fetal Programming of Human Newborn Energy Homeostasis Brain Networks And Infant AdiposityK99HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2019 to 2021
$272k
NCATS NIH HHS UL1 TR001414NICHD NIH HHS K99 HD100593NICHD NIH HHS R00 HD096109NICHD NIH HHS R00 HD100593NICHD NIH HHS R01 HD060628NIDDK NIH HHS R21 DK118578NIH HHS UG3 OD023349NIH HHS UH3 OD023349NIMH NIH HHS R01 MH091351NIMH NIH HHS R01 MH105538
6 · The paper itself

Abstract

objectiveThis study tested the hypothesis, in a prospective cohort study design, that maternal saturated free fatty acid (sFFA) concentration during pregnancy is prospectively associated with offspring (newborn) hypothalamic (HTH) microstructure and to explore the functional relevance of this association with respect to early-childhood body fat percentage (BF%).

methodsIn N = 94 healthy newborns (born mean 39.3 [SD 1.5] weeks gestation), diffusion-weighted magnetic resonance imaging was performed shortly after birth (25.3 [12.5] postnatal days), and a subgroup (n = 37) underwent a dual-energy x-ray absorptiometry scan in early childhood (4.7 [SD 0.7] years). Maternal sFFA concentration during pregnancy was quantified in fasting blood samples via liquid chromatography-mass spectrometry. Infant HTH microstructural integrity was characterized using mean diffusivity (MD). Multiple linear regression was used to test the association between maternal sFFA and HTH MD, accounting for newborn sex, age at scan, mean white matter MD, and image quality. Multiple linear regression models also tested the association between HTH MD and early-childhood BF%, accounting for breastfeeding status.

resultsMaternal sFFA during pregnancy accounted for 8.3% of the variation in newborn HTH MD (β-std = 0.25; p = 0.006). Furthermore, newborn HTH MD prospectively accounted for 15% of the variation in early-childhood BF% (β-std = 0.32; p = 0.019).

conclusionsThese findings suggest that maternal overnutrition during pregnancy may influence the development of the fetal hypothalamus, which, in turn, may have clinical relevance for childhood obesity risk.

Indexed as

Maternal Nutritional Physiological PhenomenaPediatric ObesityFatty Acids, NonesterifiedFemaleHumansHypothalamusInfant, NewbornMaternal-Fetal ExchangePregnancyProspective StudiesFatty Acids, Nonesterified

Identifiers

PMID35785481
PMCPMC9541037
OpenAlexW4283810738

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.