Evidence map›Paper›PMID 35787286›Full record

ArticleParticle and fibre toxicology2022

Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells.

Tonje Skuland, Vegard Sæter Grytting, Marit Låg, Rikke Bræmming Jørgensen, Brynhild Snilsberg, Daan L A C Leseman, Alena Kubátová, Jessica Emond, Flemming R Cassee, Jørn A Holme and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Tonje SkulandDivision of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health, PO Box 222, 0213, Skøyen, Oslo, Norway. tonje.skuland@fhi.no.
Vegard Sæter GryttingDivision of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health, PO Box 222, 0213, Skøyen, Oslo, Norway.
Marit LågDivision of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health, PO Box 222, 0213, Skøyen, Oslo, Norway.
Rikke Bræmming JørgensenDepartment of Industrial Economics and Technology Management, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Brynhild SnilsbergNorwegian Public Roads Administration, Trondheim, Norway.
Daan L A C LesemanNational Institute for Public Health and the Environment - RIVM, PO Box 1, 3720 BA, Bilthoven, The Netherlands.
Alena KubátováDepartment of Chemistry, University of North Dakota, Grand Forks, ND, USA.
Jessica EmondDepartment of Chemistry, University of North Dakota, Grand Forks, ND, USA.
Flemming R CasseeNational Institute for Public Health and the Environment - RIVM, PO Box 1, 3720 BA, Bilthoven, The Netherlands.
Jørn A HolmeDivision of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health, PO Box 222, 0213, Skøyen, Oslo, Norway.
Johan ØvrevikDivision of Climate and Environmental Health, Norwegian Institute of Public Health, PO Box 222, 0213, Skøyen, Oslo, Norway.
Magne RefsnesDivision of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health, PO Box 222, 0213, Skøyen, Oslo, Norway.
Norwegian Institute of Public Health · NOUniversity of North Dakota · USNational Institute for Public Health and the Environment · NLNorwegian Public Roads Administration · NONorwegian University of Science and Technology · NOUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraffic particulate matter (PM) comprises a mixture of particles from fuel combustion and wear of road pavement, tires and brakes. In countries with low winter temperatures the relative contribution of mineral-rich PM from road abrasion may be especially high due to use of studded tires during winter season. The aim of the present study was to sample and characterize size-fractioned PM from two road tunnels paved with different stone materials in the asphalt, and to compare the pro-inflammatory potential of these fractions in human bronchial epithelial cells (HBEC3-KT) in relation to physicochemical characteristics.

methodsThe road tunnel PM was collected with a vacuum pump and a high-volume cascade impactor sampler. PM was sampled during winter, both during humid and dry road surface conditions, and before and after cleaning the tunnels. Samples were analysed for hydrodynamic size distribution, content of elemental carbon (EC), organic carbon (OC) and endotoxin, and the capacity for acellular generation of reactive oxygen species. Cytotoxicity and pro-inflammatory responses were assessed in HBEC3-KT cells after exposure to coarse (2.5-10 μm), fine (0.18-2.5 μm) and ultrafine PM (≤ 0.18 μm), as well as particles from the respective stone materials used in the pavement.

resultsThe pro-inflammatory potency of the PM samples varied between road tunnels and size fractions, but showed more marked responses than for the stone materials used in asphalt of the respective tunnels. In particular, fine samples showed significant increases as low as 25 µg/mL (2.6 µg/cm

conclusionsThe pro-inflammatory potential of fine road tunnel PM sampled during winter season was high compared to coarse PM. The differences between the PM-induced cytokine responses were not related to stone materials in the asphalt. However, the ratio of OC to total PM mass was associated with the pro-inflammatory potential.

Indexed as

Epithelial CellsParticulate MatterCarbonCytokinesHumansSeasonsCarbonCytokinesParticulate MatterCytokinesEpithelial lung cellsMineral particlesOrganic carbonOxidative potentialStone particlesUrban air particulate matter

Identifiers

PMID35787286
PMCPMC9251916
OpenAlexW4283796422

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.