SynthesisGut2023
Genetic variation in
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Gut, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Meta-Analysis of Genetic Variants Associated With HBV Infection Susceptibility and Hepatocellular Carcinoma Risk.Journal of viral hepatitis · 2026Pooled it
- Alcohol-Associated Hepatocarcinogenesis: Wnt/β-Catenin in Action.The American journal of pathology · 2026Pooled it
- Genetic and genomic insights across the steatotic liver disease spectrum.Clinical and molecular hepatology · 2026Review
- Rare Germline Variants in Key Pathways Contribute to Hepatocellular Carcinoma Risk in Hispanic Individuals.Cancers · 2026Article
- Machine Learning Predicts Hepatocellular Carcinoma Risk from Routine Clinical Data: A Large Population-Based Multicentric Study.Cancer discovery · 2026Article
- Review
- The versatile interplay between steatotic liver disease and liver cancer.Nature reviews. Cancer · 2026Review
- Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis.Nature reviews. Gastroenterology & hepatology · 2026Review
- Lower Allele Frequency ofJCO global oncology · 2026Article
- Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways.medRxiv : the preprint server for health sciences · 2025Article
- Genome-wide meta-analysis identifies nine loci associated with higher risk of hepatocellular carcinoma development.JHEP reports : innovation in hepatology · 2025Article
- Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment.The Journal of clinical investigation · 2025Review
- Lower Frequency ofGastro hep advances · 2025Article
- Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes.Frontiers in medicine · 2025Article
- Enhancing global hepatocellular carcinoma management: Bridging Eastern and Western perspectives on dexamethasone and N-acetylcysteine before transarterial chemoembolization.World journal of gastroenterology · 2024Article
- Interpreting elevated liver blood test results through a genetic lens: A genome-wide association study.Liver international : official journal of the International Association for the Study of the Liver · 2024Article
- Association between human telomerase reverse transcriptase (hTERT) MNS16A polymorphism and risk of breast cancer.Molecular biology reports · 2024Article
- Clinical and genetic risk factors for progressive fibrosis in metabolic dysfunction-associated steatotic liver disease.Hepatology communications · 2024Article
- Alcohol-associated liver disease.The Journal of clinical investigation · 2024Review
- Cross talk between genetics and biochemistry in the pathogenesis of hepatocellular carcinoma.Hepatology forum · 2024Review
Corrections and comments
- Commented on by
Authors and funding
55 authors at 20 institutions in 10 countries.
Stephan Buch *Department of Medicine I, Dresden University Hospital, Dresden, Germany Stephan.buch@uniklinikum-dresden.de.ORCID 0000-0003-2928-015X
Hamish Innes *School of Health and Life Sciences, Glasgow Caledonian University School of Health and Life Sciences, Glasgow, UK.ORCID 0000-0003-0565-1083
Philipp Ludwig LutzDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Hans Dieter NischalkeDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Jens U MarquardtDepartment of Medicine I, University of Luebeck Human Medicine, Lubeck, Germany.
Janett FischerDepartment of Gastroenterology and Rheumatology, Section Hepatology, Leipzig University, Leipzig, Germany.
Karl Heinz WeissDepartment of Internal Medicine, Krankenhaus Salem, Heidelberg, Germany.
Jonas RosendahlDepartment of Gastroenterology, University Hospital Halle, Halle, Germany.ORCID 0000-0003-4513-0506
Astrid MarotDivision of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Center, Saarland University, Saarbrucken, Germany.
Markus CasperDepartment of Medicine II, Saarland University Medical Center, Saarland University, Saarbrucken, Germany.
Frank LammertDepartment of Medicine II, Saarland University Medical Center, Saarland University, Saarbrucken, Germany.
Florian EyerDepartment of Clinical Toxicology, Klinikum Rechts der Isar, Technical University of Munich, Munchen, Germany.
Arndt VogelDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Silke MarhenkeDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Johann von FeldenDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-2839-5174
Rohini SharmaHammersmith Hospital Campus, Imperial College, London, UK.ORCID 0000-0003-2441-549X
Stephen Rahul AtkinsonHammersmith Hospital Campus, Imperial College, London, UK.
Andrew McQuillinMolecular Psychiatry Laboratory, University College London, London, UK.
Jacob NattermannDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.ORCID 0000-0001-5972-0780
Clemens SchafmayerDepartment of General Surgery, Rostock University Medical Center, Rostock, Germany.
Andre FrankeInstitute for Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID 0000-0003-1530-5811
Christian StrassburgDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.ORCID 0000-0001-7870-5359
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Heidi AltmannDepartment of Medicine I, University Hospital Dresden, Dresden, Germany.
Stefan SulkDepartment of Medicine I, University Hospital Dresden, Dresden, Germany.
Veera Raghavan ThangapandiCenter for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany.
Mario BroschCenter for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany.
Carolin LacknerInstitute of Pathology, University of Graz, Graz, Austria.
Rudolf E StauberDepartment of Internal Medicine, University of Graz, Graz, Austria.
Ali CanbayDepartment of Internal Medicine, Ruhr-Universitat Bochum, Bochum, Germany.ORCID 0000-0001-6069-7899
Alexander LinkDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany.
Thomas ReibergerDivision of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria.ORCID 0000-0002-4590-3583
Mattias MandorferDivision of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria.ORCID 0000-0003-2330-0017
Georg SemmlerDivision of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria.
Bernhard ScheinerDivision of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria.ORCID 0000-0002-4904-5133
Christian DatzDepartment of Internal Medicine, General Hospital Oberndorf, Paracelsus Medical University Salzburg, Salzburg, Austria.ORCID 0000-0001-7838-4532
Stefano RomeoDepartment of Molecular and Clinical Medicine, University of Gothenburg, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, Gothenburg, Sweden.ORCID 0000-0001-9168-4898
Stefano Ginanni CorradiniDivision of Gastroenterology, Department of Translational and Precision Medicine, University of Rome La Sapienza, Rome, Italy.
William Lucien IrvingMicrobiology, University of Nottingham, Nottingham, UK.ORCID 0000-0002-7268-3168
Joanne R MorlingDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Indra Neil GuhaNottingham Digestive Diseases NIHR Biomedical Research Unit, University Hospital, Nottingham, UK.ORCID 0000-0002-6940-5861
Eleanor BarnesNuffield Department of Medicine, University of Oxford, Oxford, UK.
M Azim AnsariPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine and the Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Jocelyn QuistrebertPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine and the Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Luca ValentiInternal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0001-8909-0345
Sascha A MüllerDepartment of Surgery, Hirslanden Klinik Beau-Site, Bern, Switzerland.
Marsha Yvonne MorganDivision of Medicine, Royal Free Campus, UCL Institute for Liver and Digestive Health, London, UK.
Jean-François DufourDepartment of BioMedical Research, University of Bern, Bern, Switzerland.
Jonel TrebickaGastroenterology, Hepatology, Endocrinology and Clinical Infectiology, University of Münster, Münster, Germany.ORCID 0000-0002-7028-3881
Thomas BergDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig University, Leipzig, Germany.ORCID 0000-0003-0003-6241
Pierre Deltenre *Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Sebastian Mueller *Salem Medical Center, Department of Gastroenterology and Hepatology, University of Heidelberg, Heidelberg, Germany.
Jochen Hampe *Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany.ORCID 0000-0002-2421-6127
Felix Stickel *Department of Gatroenterology and Hepatology, University of Zürich, Zürich, Switzerland.
University Hospital Carl Gustav Carus · DEMedical University of Vienna · ATUniversity Medical Center · USUniversity of Bonn · DEUniversity of Oxford · GBHammersmith Hospital · GBHeidelberg University · DEMedizinische Hochschule Hannover · DEUniversity Hospital of Lausanne · CHUniversity of Graz · ATUniversity of Nottingham · GBCenter for Rheumatology · USChristian-Albrechts-Universität zu Kiel · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHirslanden Klinik Beau-Site · CHKrankenhaus Salem · DELaboratory of Molecular Genetics · PLMagna Graecia University · ITMedical University of Warsaw · PLNIHR Nottingham Digestive Diseases Biomedical Research Unit · GB
Funding
Cancer Research UK 29725Cancer Research UK C30358/A29725Department of HealthMedical Research Council MC_UU_12014/1Medical Research Council MR/K01532X/1Medical Research Council MR/P008348/1MRF_ C0365MRF_ MRF-054-0001-F-INNE-C0825
Abstract
objectiveHepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis.
designPatients with alcohol-related cirrhosis and HCC (cases: n=1214) and controls without HCC (n=1866), recruited from Germany, Austria, Switzerland, Italy and the UK, were included in a two-stage genome-wide association study using a case-control design. A validation cohort of 1520 people misusing alcohol but with no evidence of liver disease was included to control for possible association effects with alcohol misuse. Genotyping was performed using the InfiniumGlobal Screening Array (V.24v2, Illumina) and the OmniExpress Array (V.24v1-0a, Illumina).
resultsAssociations with variants rs738409 in
conclusionThis study identifies rs2242652 in
Indexed as
Carcinoma, HepatocellularGenetic Predisposition to DiseaseLiver Cirrhosis, AlcoholicLiver NeoplasmsTelomeraseCase-Control StudiesDiabetes Mellitus, Type 2Genetic VariationGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk FactorsTelomeraseTERT protein, humangenetic polymorphismshepatocellular carcinoma
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.