Evidence map›Paper›PMID 35789489›Full record

SynthesisMedical physics2022

Deep learning methods for enhancing cone-beam CT image quality toward adaptive radiation therapy: A systematic review.

Branimir Rusanov, Ghulam Mubashar Hassan, Mark Reynolds, Mahsheed Sabet, Jake Kendrick, Pejman Rowshanfarzad, Martin Ebert

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  12. Review
  13. Deep Learning for CT Synthesis in Radiotherapy.Bioengineering (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Branimir RusanovSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-3804-5111
Ghulam Mubashar HassanSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-6636-8807
Mark ReynoldsSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-5415-0544
Mahsheed SabetSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0003-1050-0749
Jake KendrickSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0001-6524-539X
Pejman RowshanfarzadSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0001-8306-7742
Martin EbertSchool of Physics, Mathematics and Computing, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-6875-0719
The University of Western Australia · AU

Funding

Australian Government Research Training Program (RTP) Scholarship 1208Cancer Council WA PhD Top Up Scholarship
6 · The paper itself

Abstract

The use of deep learning (DL) to improve cone-beam CT (CBCT) image quality has gained popularity as computational resources and algorithmic sophistication have advanced in tandem. CBCT imaging has the potential to facilitate online adaptive radiation therapy (ART) by utilizing up-to-date patient anatomy to modify treatment parameters before irradiation. Poor CBCT image quality has been an impediment to realizing ART due to the increased scatter conditions inherent to cone-beam acquisitions. Given the recent interest in DL applications in radiation oncology, and specifically DL for CBCT correction, we provide a systematic theoretical and literature review for future stakeholders. The review encompasses DL approaches for synthetic CT generation, as well as projection domain methods employed in the CBCT correction literature. We review trends pertaining to publications from January 2018 to April 2022 and condense their major findings-with emphasis on study design and DL techniques. Clinically relevant endpoints relating to image quality and dosimetric accuracy are summarized, highlighting gaps in the literature. Finally, we make recommendations for both clinicians and DL practitioners based on literature trends and the current DL state-of-the-art methods utilized in radiation oncology.

Indexed as

Deep LearningRadiotherapy Planning, Computer-AssistedCone-Beam Computed TomographyHumansImage Processing, Computer-AssistedPhantoms, ImagingRadiometryRadiotherapy Dosageadaptive radiotherapyAIcone-beam CTCTdeep learningimage synthesissynthetic CT

Identifiers

PMID35789489
PMCPMC9543319
OpenAlexW4283826630

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.