Evidence map›Paper›PMID 35789984›Full record

ArticleApplied biochemistry and biotechnology2022

Metabolomic Characterization of Acute Ischemic Stroke Facilitates Metabolomic Biomarker Discovery.

Biao Qi, Yanyu Zhang, Bing Xu, Yuhao Zhang, Guoqiang Fei, Ling Lin, Qiuping Li

Abstract read
PubMed Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Biao Qi *Department of Neurosurgery, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China.
Yanyu Zhang *Institute of Analytical Technology and Smart Instruments, Xiamen Huaxia University, Xiamen, 361024, China.
Bing Xu *Department of Emergency Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
Yuhao ZhangDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Guoqiang FeiDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Ling LinXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, 2999th Jinshan Road, Xiamen, 361000, China. linemail00@gmail.com.ORCID http://orcid.org/0000-0002-6766-5432
Qiuping LiDepartment of Neurosurgery, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China. li.qiuping@zs-hospital.sh.cn.
Sun Yat-sen University · CNFudan University · CNFujian Medical University · CNXiamen University · CN

Funding

Fujian Health Talent Training Project 2019-2-62Xiamen Medical and Health Technology Project 3502Z20194028Xiamen Medical and Health Technology Project 3502Z20194033Xiamen Science and Technology Huimin Project 3502Z20184006
6 · The paper itself

Abstract

Acute ischemic stroke (AIS) is characterized by a sudden blockage of one of the main arteries supplying blood to the brain, leading to insufficient oxygen and nutrients for brain cells to function properly. Unfortunately, metabolic alterations in the biofluids with AIS are still not well understood. In this study, we performed high-throughput target metabolic analysis on 44 serum samples, including 22 from AIS patients and 22 from healthy controls. Multiple-reaction monitoring analysis of 180 common metabolites revealed a total of 29 metabolites that changed significantly (VIP > 1, p < 0.05). Multivariate statistical analysis unraveled a striking separation between AIS patients and healthy controls. Comparing the AIS group with the control group, the contents of argininosuccinic acid, beta-D-glucosamine, glycerophosphocholine, L-abrine, and L-pipecolic acid were remarkably downregulated in AIS patients. Twenty-nine out of 112 detected metabolites enriched in disturbed metabolic pathways, including aminoacyl-tRNA biosynthesis, glycerophospholipid metabolism, lysine degradation, phenylalanine, tyrosine, and tryptophan biosynthesis metabolic pathways. Collectively, these results will provide a sensitive, feasible diagnostic prospect for AIS patients.

Indexed as

Ischemic StrokeStrokeArgininosuccinic AcidBiomarkersGlucosamineGlycerophospholipidsHumansLysineMetabolomicsOxygenPhenylalanineRNA, TransferTryptophanTyrosineArgininosuccinic AcidBiomarkersGlucosamineGlycerophospholipidsLysineOxygenPhenylalanineRNA, TransferTryptophanTyrosineAcute ischemic strokeGlycerophospholipid metabolismHuman serum biomarkersLysine degradationTargeted metabolomics

Identifiers

PMID35789984
OpenAlexW4283819329

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.