Evidence map›Paper›PMID 35790434›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Inhibition of Sonic Hedgehog signaling inhibits fibrous scar formation and adversely affects functional outcome after ischemic brain injury in rats].

J Wen, H Zhu, X Li, J Huang, Y Chen, Q Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J WenDepartment of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
H ZhuDepartment of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
X LiDepartment of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
J HuangDepartment of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Y ChenDepartment of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Q YangDepartment of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chongqing Medical University · CNFirst Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of inhibiting Sonic Hedgehog (Shh) signaling on fibrous scar formation and functional outcome after ischemic brain injury.

methodsAdult SD rats were randomized into sham-operated group, middle cerebral artery occlusion (MCAO) and reperfusion (I/R) group, I/R with intraventricular empty adenoviral vector (rAd-NC) injection group, and I/R with adenovirus-mediated Shh knockdown (rAd-ShShh) group. After the treatments, the neurological deficits of the rats were assessed, and the protein and mRNA expressions of fibronectin (Fn),

resultsCerebral I/R injury significantly increased the protein and mRNA expressions of Shh,

conclusionInhibition of Shh signaling may inhibit fibrous scar formation and functional recovery in rats after ischemic brain injury.

Indexed as

Brain InjuriesHedgehog ProteinsAnimalsCicatrixRatsRats, Sprague-DawleyRNA, MessengerTransforming Growth Factor beta1Hedgehog ProteinsRNA, MessengerTransforming Growth Factor beta1cerebral ischemiafibro-blastsmyofibroblastsShh signaling

Identifiers

PMID35790434
PMCPMC9257362
OpenAlexW4283827118

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.