Evidence map›Paper›PMID 35792570›Full record

ArticleCannabis and cannabinoid research2023

The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor.

Luciana M Leo, Rufaida Al-Zoubi, Dow P Hurst, Anna P Stephan, Pingwei Zhao, Douglas G Tilley, Elke Miess, Stefan Schulz, Mary E Abood, Patricia H Reggio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cannabis and cannabinoid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Luciana M LeoCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Rufaida Al-ZoubiDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science & Technology, Irbid, Jordan.
Dow P HurstChemistry and Biochemistry Department, UNC Greensboro, Greensboro, North Carolina, USA.
Anna P StephanCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Pingwei ZhaoCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Douglas G TilleyCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Elke MiessDepartment of Pharmacology and Toxicology, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany.
Stefan SchulzDepartment of Pharmacology and Toxicology, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany.
Mary E AboodCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1744-2820
Patricia H ReggioChemistry and Biochemistry Department, UNC Greensboro, Greensboro, North Carolina, USA.
Temple University · USJena University Hospital · DEUniversity of North Carolina at Greensboro · USJordan University of Science and Technology · JO

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI SCOTT M. RAWLS · 2000 to 2026
$34.6M
TRAINING PROGRAM: DRUGS OF ABUSE RELATED NEUROPEPTIDEST32DA007237 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLEN M UNTERWALD · 1988 to 2026
$10.6M
Molecular Determinants of Cannabinoid ActivityR01DA003934 · NIDA · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI REGGIO, PATRICIA HODAPP · 1985 to 2019
$5.6M
Molecular Determinants of GPR55 ActivityR01DA045698 · NIDA · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI CROATT, MITCHELL PETER · 2018 to 2022
$1.7M
NIDA NIH HHS P30 DA013429NIDA NIH HHS R01 DA003934NIDA NIH HHS R01 DA045698NIDA NIH HHS T32 DA007237
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

beta-Arrestin 1Receptor, Cannabinoid, CB1beta-ArrestinsCannabinoidsGTP-Binding ProteinsHEK293 CellsHumansReceptors, G-Protein-CoupledARRB1 protein, humanbeta-Arrestin 1beta-ArrestinsCannabinoidsGTP-Binding ProteinsReceptor, Cannabinoid, CB1Receptors, G-Protein-Coupledbeta-arrestinbiased signalingCB1GPCRNPXXY

Identifiers

PMID35792570
PMCPMC10589503
OpenAlexW4283825713

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.