SynthesisInternational journal of stroke : official journal of the International Stroke Society2023
Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.
Synthesis in International journal of stroke : official journal of the International Stroke Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- DTI-ALPS index and cognitive impairment in cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Chinese medicine interventions for cerebral small vessel disease-related cognitive impairment: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Laboratory-based turning performance during walking in people with mild cognitive impairment and dementia.Journal of Alzheimer's disease : JAD · 2026Article
- Turning as a single and dual task-associations with Alzheimer's and vascular pathologies in cognitively healthy older people.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Magnetic Resonance Imaging- Derived Cerebral Small Vessel Disease Burden and Association with Domain-Specific Cognition: A Cross-Sectional Study.Annals of Indian Academy of Neurology · 2026Article
- Gait-Based Screening for Cognitive Impairment in Older Adults: A Fast and Objective Approach.Healthcare (Basel, Switzerland) · 2025Article
- Gait anomaly detection based on video-derived 3D pose estimation.Medical & biological engineering & computing · 2025Article
- The effect of cognition on the association between cerebral small vessel disease burden and motor function: a cross-sectional study.European journal of medical research · 2025Article
- Gait Disturbances in Older Adults With Cerebral Small Vessel Disease: Mixed Methods Study Using Smartphone Sensors and Video Analysis.JMIR formative research · 2025Article
- ARTS is associated with vascular risk factors, MCI, dementia, and stroke.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Smaller cingulate grey matter mediates the association between dual-task gait and incident dementia.Brain : a journal of neurology · 2025Article
- Discrepant Spatiotemporal Characteristics of Gait Impairments in Thalamic Infarction Patients.Brain and behavior · 2025Article
- Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.Brain structure & function · 2025Article
- Analysis of the impact of cerebral small vessel disease on neurological outcomes in patients with basal ganglia/corona radiata ischemic stroke treated with intravenous thrombolysis under multimodal MRI guidance.Frontiers in neurology · 2025Article
- Wearable sensors and machine learning fusion-based fall risk prediction in covert cerebral small vessel disease.Frontiers in neuroscience · 2025Article
- Chronic Cerebral Deterioration - A Comprehensive View of Old-Age Cerebral Deterioration.Aging and disease · 2024Review
- Artificial intelligence-assisted oculo-gait measurements for cognitive impairment in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease.Brain : a journal of neurology · 2024Article
- Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe interrelationships between gait, cerebral small vessel disease (CSVD), and cognitive impairments in aging are not well-understood-despite their common co-occurrence.
objectiveTo systematically review studies of gait impairment in CSVD, pre-dementia, and dementia, and to identify key gaps for future research and novel pathways toward intervention.
methodsA Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided search strategy was implemented in PubMed to identify relevant studies. Potential articles (n = 263) published prior to 1 December 2021 were screened by two reviewers. Studies with sample sizes >20 and including some adults over > 65 years (n = 202) were included.
resultsThe key findings were that (1) adverse gait and cognitive outcomes were associated with several (rather than select) CSVD pathologies distributed across the brain, and (2) poor gait and CSVD pathologies were more strongly associated with dementia with a vascular, rather than an Alzheimer's disease-related, cause. DISCUSSION: A better understanding of the interrelationships between gait performance in CSVD, pre-dementia, and dementia requires studies examining (1) comprehensive patterns in the clinical manifestations of CSVD, (2) racially/ethnically diverse samples, (3) samples followed for extended periods of time or across the adult life span, (4) non-traditional CSVD neuroimaging markers (e.g. resting-state functional magnetic resonance imaging (fMRI)), and (5) continuous (e.g. wearable sensors) and complex (e.g. dual-task) walking performance.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.