ArticleEpidemiology and health2022
Blood lipid levels and all-cause mortality in older adults: the Chinese Longitudinal Healthy Longevity Survey 2008-2018.
Article in Epidemiology and health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- How Tea Consumption Interacts with Genetics to Affect Cardiovascular Biomarkers in Older Adults? Findings from the CLHLS.Research square · 2025Article
- Relationship Between Activity Tracker Metrics and the Physical Activity Index and Their Association With Cardiometabolic Phenotypes, Subclinical Atherosclerosis, and Cardiac Remodeling: Cross-Sectional Study.JMIR mHealth and uHealth · 2025Article
- Osteoporosis risk and its association with all-cause and cause-specific mortality among the elderly: a 16-year nationwide cohort study.BMC geriatrics · 2025Article
- Effects of Lipoproteins on Metabolic Health.Nutrients · 2024Review
- Predictive Value of Triglyceride-Glucose Index for All-Cause and Cardiovascular Mortality in Patients With Diabetes Mellitus: A Retrospective Study: TyG Index and Mortality in Diabetes.International journal of endocrinology · 2024Article
- Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study.Frontiers in public health · 2024Article
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Authors and funding
17 authors.
Funding
Abstract
objectivesProper blood lipid levels are essential for survival in older adults, but inconsistent relationships have been reported between blood lipids and all-cause mortality in the elderly.
methodsThis retrospective longitudinal study analyzed data from 1,067 Chinese older adults enrolled in the Chinese Longitudinal Healthy Longevity Survey collected in 2008 and followed up until death or December 31, 2018. The outcome was all-cause mortality. Multivariate Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with stratification by age (60-80, 80-100, or ≥100 years) for further analysis. The survival probability according to lipid profile quartiles was calculated using Kaplan-Meier curves and the log-rank test.
resultsThe participants' mean age was 84.84 years, and 57.0% were female. In total, 578 individuals died, and 277 were lost to follow-up. The mean total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were higher among those who died than among those who survived. Participants in the second HDL-C quartile and the highest LDL-C and triglyceride (TG) quartiles had 28% higher, 23% lower, and 49% lower risks of all-cause mortality, respectively. After further adjustment, the associations remained except for HDL-C, and additional associations were observed between all-cause mortality and the third TC and LDL-C quartiles and the second TG quartile (HR, 1.44; 95% CI, 1.01 to 2.06; HR, 0.68; 95% CI, 0.49 to 0.94; HR, 0.79; 95% CI, 0.62 to 0.99, respectively).
conclusionsOlder adults should maintain an LDL-C level of 1.91-2.47 mmol/L and a TG level of no less than 1.66 mmol/L.
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