Evidence map›Paper›PMID 35799022›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2023

Research Progress in the Relationship Between P2X7R and Cervical Cancer.

Yiqing Tang, Cuicui Qiao, Qianqian Li, Xiaodi Zhu, Ronglan Zhao, Xiaoxiang Peng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yiqing TangSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China.
Cuicui QiaoSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China.
Qianqian LiSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China.
Xiaodi ZhuSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China.
Ronglan ZhaoSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China. zhaoronglan76@sina.com.ORCID 0000-0002-4302-2563
Xiaoxiang PengSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China. pxx74@sina.com.ORCID 0000-0001-6339-0462
Weifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is one of the most common and serious tumors in women. Finding new biomarkers and therapeutic targets plays an important role in the diagnosis, prognosis, and treatment of cervical cancer. Purinergic ligand-gated ion channel 7 receptor (P2X7R) is a purine ligand cation channel, activated by adenosine triphosphate (ATP). Studies have shown that P2X7R plays an important role in a variety of diseases and cancers. More and more studies have shown that P2X7R is also closely related to cervical cancer; therefore, the role of P2X7R in the development of cervical cancer deserves further discussion. The expression level of P2X7R in uterine epithelial cancer tissues was lower than that of the corresponding normal tissues. P2X7R plays an important role in the apoptotic process of cervical cancer through various mechanisms of action, and both antagonists and agonists of P2X7R can inhibit the proliferation of cervical cancer cells, while P2X7R is involved in the antitumor effect of Atr-I on cervical cancer cells. This review evaluates the current role of P2X7R in cervical cancer in order to develop more specific therapies for cervical cancer. In conclusion, P2X7R may become a biomarker for cervical cancer screening, and even a new target for clinical treatment of cervical cancer.

Indexed as

Uterine Cervical NeoplasmsAdenosine TriphosphateApoptosisBiomarkersCervix UteriEarly Detection of CancerFemaleHumansPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Adenosine TriphosphateBiomarkersPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Adenosine triphosphateApoptosisCervical cancerP2X7 receptor

Identifiers

PMID35799022
OpenAlexW4284895741

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.