Evidence mapPaperPMID 35803221Full record

ArticleCell stem cell2022

Mini kidney organoids deliver maximal drug screening impact.

Eryn E Dixon, Shayna T J Bradford, Benjamin D Humphreys

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Eryn E DixonDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Shayna T J BradfordDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Benjamin D HumphreysDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: humphreysbd@wustl.edu.

Funding

RENAL DISEASET32DK007126 · WASHINGTON UNIVERSITY · 1986 to 2004
$2.3M
NIDDK NIH HHS T32 DK007126
6 · The paper itself

Abstract

In this issue of Cell Stem Cell, Tran and colleagues develop a platform for differentiating thousands of miniature kidney organoids consisting of one or two nephron-like structures each. They use this platform to identify a potent new inhibitor of cyst growth in organoid models of autosomal-dominant polycystic kidney disease.

Indexed as

KidneyOrganoidsDrug Evaluation, PreclinicalNephrons

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.