ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
Hypermagnesemia and hyperphosphatemia are highly prevalent in patients with COVID-19 and increase the risk of death.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review.BioMed research international · 2022Pooled it
- Admission Electrolyte Abnormalities and Clinical Outcomes in Hospitalized COVID-19 Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Association between serum phosphate levels and 28-day mortality in patients with sepsis-associated liver injury: a cohort study.BMC infectious diseases · 2025Article
- Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units.Experimental and therapeutic medicine · 2024Article
- The predictive role of biochemical markers on outcomes of severe COVID-19 patients admitted to intensive care unit.Journal of medical biochemistry · 2023Article
- Electrolyte abnormalities in hospitalized COVID-19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross-sectional study.Health science reports · 2023Article
- Prevalence and predictors of magnesium imbalance among critically ill diarrheal children and their outcome in a developing country.PloS one · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNonrespiratory manifestations of COVID-19 include endocrine disorders, among which are calcium-magnesium-phosphate homeostasis abnormalities, which seem to influence the disease severity and patient outcome. The aim of this study was to evaluate the prevalence and impact of calcium-magnesium-phosphate and vitamin D3 disorders on survival in patients hospitalized for COVID-19 depending on the severity of the disease and kidney function. DESIGN OR
methodsThe study was conducted between April 2020 and May 2021 at Central Clinical Hospital in Warsaw, Poland. A total of 146 patients who had tested concentration of at least one of the studied elements, estimated glomerular filtration ratio, creatinine levels, and blood saturation, and were diagnosed with COVID-19 disease were included in the analysis.
resultsWe found that hypermagnesemia was common and associated with a 1.5-fold increased risk of death in the whole cohort. Hyperphosphatemia also increased the risk of death, exactly 2.4-fold. Furthermore, we found a statistically significant association between increased mortality in the whole cohort and hypovitaminosis D3 (P <0.05). Serum creatinine concentration and estimated glomerular filtration ratio significantly correlated with serum magnesium and phosphate levels.
conclusionHypermagnesemia, hyperphosphatemia, and hypovitaminosis D but not hypocalcemia influence the mortality of patients with COVID-19. These parameters should be monitored routinely in this group of patients, especially in those with decreased kidney function.
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