Evidence map›Paper›PMID 35806020›Full record

ArticleInternational journal of molecular sciences2022

Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes.

José Thalles Lacerda, Patrícia R L Gomes, Giovanna Zanetti, Nathana Mezzalira, Otoniel G Lima, Leonardo V M de Assis, Ali Guler, Ana Maria Castrucci, Maria Nathália Moraes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. The Role of Cannabidiol in Liver Disease: A Systemic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Lack of GPNMB Is Associated With Altered Lipid and Glucose Metabolism and Disrupted Diurnal Hepatic Glycogen Regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Review
  4. Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

José Thalles LacerdaLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0003-4588-7197
Patrícia R L GomesLaboratory of Neurobiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Giovanna ZanettiLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-0668-3063
Nathana MezzaliraLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.
Otoniel G LimaLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.
Leonardo V M de AssisLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0001-5209-0835
Ali GulerDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Ana Maria CastrucciLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-2065-8198
Maria Nathália MoraesLaboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0003-2479-4477
Universidade de São Paulo · BRUniversity of Virginia · US

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001National Council for Scientific and Technological Development 301293/2011-2, 303070/2015-3, 428754/2018-0São Paulo Research Foundation 2018/14728-0, 2017/24615-5, 2012/50214-4, 2017/26651-9, 2019/19005-9, 2014/16412-9, 2020/04524-8, 2021/09923-0, 2018/23915-8, 2021/01659-2, 2018/16511-8 and 2013/02131-5
6 · The paper itself

Abstract

To investigate the role of the transient receptor potential channel vanilloid type 1 (TRPV1) in hepatic glucose metabolism, we analyzed genes related to the clock system and glucose/lipid metabolism and performed glycogen measurements at ZT8 and ZT20 in the liver of C57Bl/6J (WT) and

Indexed as

GluconeogenesisProteomeTRPV Cation ChannelsAnimalsGene ExpressionGlucoseGlycogenLiverMiceMice, Inbred C57BLMice, KnockoutGlucoseGlycogenProteomeTRPV1 protein, mouseTRPV Cation Channelsgluconeogenesisglycogenolysisliver clock and glucose metabolism genesproteomics

Identifiers

PMID35806020
PMCPMC9266899
OpenAlexW4283573966

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.