Evidence map›Paper›PMID 35806965›Full record

ArticleJournal of clinical medicine2022

Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease.

Sara Souto-Miranda, Alex J van 't Hul, Anouk W Vaes, Jeanine C Antons, Remco S Djamin, Daisy J A Janssen, Frits M E Franssen, Alda Marques, Martijn A Spruit

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Can Treatable Traits Be the Approach to Addressing the Complexity and Heterogeneity of COPD?International journal of chronic obstructive pulmonary disease · 2023
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Management Reality of Female Patients with COPD: A Multicenter Cross-Sectional CAP Study in Japan.International journal of chronic obstructive pulmonary disease · 2024
    Observational
  8. Article
  9. Review
  10. Article
  11. Editorial: Women in science: Pulmonary rehabilitation.Frontiers in rehabilitation sciences · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Sara Souto-MirandaDepartment of Research and Development, Ciro, 6085 NM Horn, The Netherlands.ORCID 0000-0002-5984-4844
Alex J van 't HulDepartment of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-5514-2327
Anouk W VaesDepartment of Research and Development, Ciro, 6085 NM Horn, The Netherlands.ORCID 0000-0002-4136-1553
Jeanine C AntonsDepartment of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Remco S DjaminDepartment of Respiratory Diseases, Amphia Hospital, 4818 CK Breda, The Netherlands.
Daisy J A JanssenDepartment of Research and Development, Ciro, 6085 NM Horn, The Netherlands.ORCID 0000-0002-1827-9869
Frits M E FranssenDepartment of Research and Development, Ciro, 6085 NM Horn, The Netherlands.
Alda MarquesRespiratory Research and Rehabilitation Laboratory (Lab3R) and Institute of Biomedicine (iBiMED), University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-4980-6200
Martijn A SpruitDepartment of Research and Development, Ciro, 6085 NM Horn, The Netherlands.ORCID 0000-0003-3822-7430
Maastricht University Medical Centre · NLRadboud University Nijmegen · NLAmphia Ziekenhuis · NLCiro · NLMaastricht University · NLUniversity of Aveiro · PT

Funding

Ciro Ciro+ Short-term Research Training Fellowship 2021Fundação para a Ciência e Tecnologia SFRH/BD/146134/2019Fundação para a Ciência e Tecnologia UIDB/04501/2020
6 · The paper itself

Abstract

Background: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown. Methods: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differences were tested using t-tests, Mann-Whitney U, or chi-square tests. Results: Frequent exacerbations (30.5 vs. 19.7%), high cardiovascular risk (88.1 vs. 66.2%) and activity-related severe dyspnea (50.9 vs. 34.8%) were more prevalent in women in secondary care (p < 0.05). Severe hyperinflation (43.0 vs. 25.4%), limited diffusing capacity (79.6 vs. 70.1%), impaired mobility (44.0 vs. 28.7%), frequent exacerbations (66.8 vs. 57.4%), frequent hospitalizations (47.5 vs. 41.6%), severe activity-related dyspnea (89.1 vs. 85.0%), symptoms of anxiety (56.3 vs. 42.0%) and depression (50.3 vs. 44.8%), and poor health status (79.9 vs. 71.0%) were more prevalent in women in tertiary care (p < 0.05). Severe inspiratory muscle weakness (14.6 vs. 8.2%) and impaired exercise capacity (69.1 vs. 59.6%) were more prevalent among men (p < 0.05) in tertiary care. Conclusions: Sex-related differences were found, with most traits more prevalent and severe among women. Care providers should be aware of these differences to adjust treatment.

Indexed as

COPDgendersex-related differencestreatable traits

Identifiers

PMID35806965
PMCPMC9267757
OpenAlexW4283583108

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.