Evidence map›Paper›PMID 35807390›Full record

ArticleMolecules (Basel, Switzerland)2022

Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na

Quentin Coquerel, Claire Legendre, Jacinthe Frangieh, Stephan De Waard, Jérôme Montnach, Leos Cmarko, Joseph Khoury, Charifat Said Hassane, Dimitri Bréard, Benjamin Siegler and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Quentin CoquerelUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.ORCID 0000-0001-9382-337X
Claire LegendreUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.
Jacinthe FrangiehUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.ORCID 0000-0002-3413-8732
Stephan De WaardNantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.ORCID 0000-0003-4236-6687
Jérôme MontnachNantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.ORCID 0000-0001-5100-5571
Leos CmarkoNantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.ORCID 0000-0003-4272-2784
Joseph KhouryUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.
Charifat Said HassaneUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.ORCID 0000-0002-8953-0328
Dimitri BréardUniv Angers, SONAS, SFR QUASAV, 49100 Angers, France.ORCID 0000-0001-6477-9592
Benjamin SieglerUniv Angers, SONAS, SFR QUASAV, 49100 Angers, France.
Ziad FajlounLaboratory of Applied Biotechnology, AZM Centre for Research in Biotechnology and Its Application, Doctoral School for Sciences and Technology, Tripoli 1352, Lebanon.ORCID 0000-0002-6502-3110
Harold De PomyersLatoxan Laboratory, 26800 Portes lès Valence, France.
Kamel MabroukCNRS, ICR, Aix Marseille Univ, 13397 Marseille, France.
Norbert WeissDepartment of Pathophysiology, First Faculty of Medicine, Charles University, 160 00 Prague, Czech Republic.ORCID 0000-0002-0040-1109
Daniel HenrionUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.ORCID 0000-0003-1094-0285
Pascal RichommeUniv Angers, SONAS, SFR QUASAV, 49100 Angers, France.
César MatteiUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.ORCID 0000-0002-2214-2611
Michel De WaardNantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.ORCID 0000-0002-2782-9615
Anne-Marie Le RayUniv Angers, SONAS, SFR QUASAV, 49100 Angers, France.
Christian LegrosUniv Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.ORCID 0000-0002-3346-7059
Centre National de la Recherche Scientifique · FRUniversité d'Angers · FRCharles University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated Na

Indexed as

AlkaloidsFluorescent DyesBatrachotoxinsBiasHEK293 CellsHumansIsoquinolinesLigandsSodiumAlkaloidsBatrachotoxinsFluorescent DyesIsoquinolinesLigandsSodiumGH3b6 cellsisoquinoline alkaloidsNa+ fluorescent probe ANG-2oxoaporphinevoltage-gated sodium channelvoltage sensor probes

Identifiers

PMID35807390
PMCPMC9268414
OpenAlexW4283704817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.