Evidence map›Paper›PMID 35809063›Full record

ArticleBioinformatics (Oxford, England)2022

RNAloops: a database of RNA multiloops.

Jakub Wiedemann, Jacek Kaczor, Maciej Milostan, Tomasz Zok, Jacek Blazewicz, Marta Szachniuk, Maciej Antczak

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. When will RNA get its AlphaFold moment?Nucleic acids research · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jakub WiedemannInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.
Jacek KaczorInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.
Maciej MilostanInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.
Tomasz ZokInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.ORCID 0000-0003-4103-9238
Jacek BlazewiczInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.
Marta SzachniukInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.ORCID 0000-0002-8724-7908
Maciej AntczakInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland.ORCID 0000-0002-5320-2023

Funding

Institute of Bioorganic ChemistryNational Science Center 2019/35/B/ST6/03074Poznan University of Technology 0311/SBAD/0705
6 · The paper itself

Abstract

motivationKnowledge of the 3D structure of RNA supports discovering its functions and is crucial for designing drugs and modern therapeutic solutions. Thus, much attention is devoted to experimental determination and computational prediction targeting the global fold of RNA and its local substructures. The latter include multi-branched loops-functionally significant elements that highly affect the spatial shape of the entire molecule. Unfortunately, their computational modeling constitutes a weak point of structural bioinformatics. A remedy for this is in collecting these motifs and analyzing their features.

resultsRNAloops is a self-updating database that stores multi-branched loops identified in the PDB-deposited RNA structures. A description of each loop includes angular data-planar and Euler angles computed between pairs of adjacent helices to allow studying their mutual arrangement in space. The system enables search and analysis of multiloops, presents their structure details numerically and visually, and computes data statistics. AVAILABILITY AND IMPLEMENTATION: RNAloops is freely accessible at https://rnaloops.cs.put.poznan.pl. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

RNASoftwareDatabases, FactualNucleic Acid ConformationSequence Analysis, RNARNA

Identifiers

PMID35809063
PMCPMC9438955

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.