Evidence map›Paper›PMID 35809206›Full record

Trial reportAging clinical and experimental research2022

Effect of transcutaneous auricular vagus nerve stimulation on delayed neurocognitive recovery in elderly patients.

Qi Zhou, Lili Yu, Chunping Yin, Qi Zhang, Xupeng Wang, Kai Kang, Decheng Shao, Qiujun Wang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qi ZhouDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Lili YuDepartment of Anesthesiology, Cangzhou Central Hospital, Cangzhou, China.
Chunping YinDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Qi ZhangDepartment of Anesthesiology, Hebei Children's Hospital Affiliated to Hebei Medical University, Shijiazhuang, China.
Xupeng WangDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Kai KangDepartment of Joint Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Decheng ShaoDepartment of Sport Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Qiujun WangDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China. wangqiujunsy@163.com.
Hebei Medical University · CNCangzhou Central Hospital · CNThird Hospital of Hebei Medical University · CN

Funding

Innovation guide Project Science and Technology Winter Olympics special project 19977790DNational Natural Science Foundation of China 81771134
6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate whether transauricular vagus nerve stimulation (taVNS) could decrease the incidence of delayed neurocognitive recovery (dNCR) in elderly adults after total joint arthroplasty (TJA).

methodsA prospective, randomized, double-blind, sham-controlled trial was designed. In total, 124 elderly patients undergoing TJA were enrolled and randomly assigned to taVNS group (n = 62), who received taVNS at 1 h before anesthetic induction until the end of surgery, or sham stimulation (SS) group (n = 62), who received SS in the same manner. Neuropsychological batteries were performed before and at 1 week after surgery to assess the incidence of dNCR. Blood samples were collected before surgery and at 1 day after surgery to detect the activity of cholinesterase (AChE and BChE), as well as the levels of inflammatory factors (TNF-α, IL-1β, IL-6, and HMGB1) and brain damage factor S100β.

resultsOf 124 patients, 119 completed 1 week neuropsychological tests. The incidence of dNCR was significantly decreased in taVNS group [10% (6/60)] compared with the SS group [27.1% (16/59)] (P < 0.05). Patients who received taVNS had lower blood levels of AChE, BChE, IL-6, HMGB1, and S100β after surgery (P < 0.05), as compared with those in the SS group. There was no difference in TNF-α between the two groups.

conclusionThe taVNS can decrease the incidence of dNCR after TJA in elderly patients, which may be related to the inhibition of inflammatory cytokine production and the reduction of cholinesterase activity.

Indexed as

ArthroplastyCognitionVagus Nerve StimulationAgedCholinesterasesHMGB1 ProteinHumansInterleukin-6Neuropsychological TestsProspective StudiesTumor Necrosis Factor-alphaCholinesterasesHMGB1 ProteinInterleukin-6Tumor Necrosis Factor-alphaCholinesteraseInflammationPostoperative cognitive declineTransauricular vagus nerve stimulation

Identifiers

PMID35809206
OpenAlexW4284965239

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.