Evidence map›Paper›PMID 35812437›Full record

SynthesisFrontiers in immunology2022

Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis.

Shengya Wang, Huayi Zhou, Changtao Zhao, Hui He

Open access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 15 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 15 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  16. Synergistic Effects of High-Intensity Interval Training andInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shengya WangDepartment of Exercise Physiology, Beijing Sport University, Beijing, China.
Huayi ZhouDepartment of Exercise Physiology, Beijing Sport University, Beijing, China.
Changtao ZhaoDepartment of Physical Health and Arts Education, Ministry of Education, Beijing, China.
Hui HeChina Institute of Sport and Health Science, Beijing Sport University, Beijing, China.
Beijing Sport University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to compare and rank the effectiveness of aerobic exercise (AE), resistance training (RT), combined aerobic and resistance training (CT), and high-intensity interval training (HIIT) on body composition and inflammatory cytokine levels in overweight and obese individuals by using network meta-analysis (NMA). Methods: We searched the PubMed, Cochrane, Embase, Web of Science, and EBSCO databases to identify randomized controlled trials investigating the effects of exercise training on inflammatory cytokines in overweight and obese patients. The retrieval period was from inception to November 2021. Two reviewers independently screened the retrieved articles, extracted the pertinent data, and assessed the risk of bias of the included studies; then, they used Stata 16.0 and Review Manager 5.3 to perform an NMA. Results: A total of 38 studies involving 1317 patients were included in this study. The results of the NMA indicated that AE had the greatest effect on weight loss (SUCRA=78.3; SMD=-0.51, 95% CI: -0.70, -0.33); CT had the greatest effect on reducing body mass index (SUCRA=70.7; SMD=-0.46, 95% CI: -0.81, -0.10), waist circumference (SUCRA=93.4; SMD=-1.86, 95% CI: -2.80, -0.93), percentage body fat (SUCRA=79.6; SMD=-1.38, 95% CI: -2.29, -0.48), interleukin-6 level (SUCRA=86.4; SMD=-1.98, 95% CI: -3.87, -0.09), and tumor necrosis factor-α level (SUCRA=79.4; SMD=-2.08, 95% CI: -3.75, -0.42); AE (SMD=0.51, 95% CI: -1.68, 2.69), RT (SMD=0.15, 95% CI: -3.01, 3.32), CT (SMD=1.78, 95% CI: -1.35, 4.92), and HIIT (SMD=2.29, 95% CI: -1.27, 5.86) did not significantly increase the adiponectin level. Conclusion: The current results suggest that CT is the best exercise modality for improving body composition and inflammatory status in overweight and obese individuals. More rigorous randomized control trials are needed for further validation. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42022303165.

Indexed as

CytokinesOverweightBody CompositionExerciseHumansObesityWeight LossCytokinesbody compositionexerciseinflammatory cytokinenetwork meta-analysisoverweight and obese individuals

Identifiers

PMID35812437
PMCPMC9260601
OpenAlexW4283323961

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.