Evidence map›Paper›PMID 35812759›Full record

ArticleFrontiers in genetics2022

Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of

Karen C Clark, Valerie A Wagner, Katie L Holl, John J Reho, Monika Tutaj, Jennifer R Smith, Melinda R Dwinell, Justin L Grobe, Anne E Kwitek

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Karen C ClarkDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Valerie A WagnerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Katie L HollDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
John J RehoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Monika TutajDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States.
Jennifer R SmithDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States.
Melinda R DwinellDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Justin L GrobeDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Anne E KwitekDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Medical College of Wisconsin · US

Funding

RAT GENOME DATABASER01HL064541 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ANNE E. KWITEK · 1999 to 2026
$50.0M
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1M
Dissecting the genetics of the Metabolic Syndrome on Chromosome 17 of the LH ratR01HL089895 · NHLBI · UNIVERSITY OF IOWA · PI KWITEK, ANNE E. · 2008 to 2012
$1.7M
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL064541NHLBI NIH HHS R01 HL089895NIGMS NIH HHS T32 GM008629
6 · The paper itself

Abstract

Central obesity is genetically complex, and its exponential increase in the last decades have made it a critical public health issue. The Lyon Hypertensive (LH) rat is a well-characterized hypertensive model that also exhibits spontaneous and profound differences in body weight and adiposity, relative to its metabolically healthy control, the Lyon Normotensive (LN) rat. The mechanisms underlying the body weight differences between these strains are not well-understood, thus a congenic model (LH

Indexed as

adipocyte hypertrophybody weightcongenic ratERCC6L2 genefat distributionmetabolismQTL mappingrat model

Identifiers

PMID35812759
PMCPMC9263446
OpenAlexW4283449841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.