Evidence map›Paper›PMID 35814209›Full record

ArticleFrontiers in pharmacology2022

Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis.

Ying Lai, Michael J Tuvim, Jeremy Leitz, John Peters, Richard A Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B Cross, Philip Jones and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The Core Complex of the CaJournal of molecular biology · 2023
    Review
  3. Review
  4. Discovery of a drug to treat airway mucus hypersecretion.Clinical and translational medicine · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ying LaiDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
Michael J TuvimDepartment of Pulmonary Medicine, MD Anderson Cancer Center, University of Texas, Houston, TX, United States.
Jeremy LeitzDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
John PetersDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
Richard A PfuetznerDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
Luis EsquiviesDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
Qiangjun ZhouDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
Barbara CzakoInstitute for Applied Cancer Science, MD Anderson Cancer Center, University of Texas, Houston, TX, United States.
Jason B CrossInstitute for Applied Cancer Science, MD Anderson Cancer Center, University of Texas, Houston, TX, United States.
Philip JonesInstitute for Applied Cancer Science, MD Anderson Cancer Center, University of Texas, Houston, TX, United States.
Burton F DickeyDepartment of Pulmonary Medicine, MD Anderson Cancer Center, University of Texas, Houston, TX, United States.
Axel T BrungerDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States.
Stanford University · USThe University of Texas MD Anderson Cancer Center · USHoward Hughes Medical Institute · US

Funding

STRUCTURE OF PROTEINS INVOLVED IN SYNAPTIC EXOCYTOSISR01MH063105 · NIMH · STANFORD UNIVERSITY · PI BRUNGER, AXEL T · 2000 to 2025
$4.7M
Controlling the core airway mucin secretion machinery to prevent pathophysiologyR01HL129795 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DICKEY, BURTON F · 2015 to 2023
$3.8M
Molecular Mechanism and Regulation of Asynchronous ReleaseR00MH113764 · NIMH · VANDERBILT UNIVERSITY · PI ZHOU, QIANGJUN · 2020 to 2022
$719k
Molecular Mechanism and Regulation of Asynchronous ReleaseK99MH113764 · NIMH · STANFORD UNIVERSITY · PI ZHOU, QIANGJUN · 2017 to 2018
$223k
NHLBI NIH HHS R01 HL129795NIMH NIH HHS K99 MH113764NIMH NIH HHS R00 MH113764NIMH NIH HHS R01 MH063105
6 · The paper itself

Abstract

The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca

Indexed as

airway obstructionasthmacystic fibrosismucin secretionneurotransmitter releasestapled peptidestimulated membrane fusion

Identifiers

PMID35814209
PMCPMC9258623
OpenAlexW4283010301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.