ArticleFrontiers in cardiovascular medicine2021
Protein S Deficiency and the Risk of Venous Thromboembolism in the Han Chinese Population.
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Pedigree analysis of cerebral venous sinus thrombosis associated with compound heterozygous hereditary protein S deficiency.Annals of hematology · 2026Article
- The prevalence of FV Hong Kong in patients with thrombotic disorders in South China.Journal of thrombosis and thrombolysis · 2026Article
- Blood coagulation factors and risk of venous thromboembolism: a population-based study.European journal of medical research · 2026Article
- Case Report: Severe protein S deficiency unmasks a crypticFrontiers in cardiovascular medicine · 2026Article
- A pedigree analysis of deep venous thrombosis caused by rare compound heterozygous PROC mutations combined with a heterozygous THBD mutation.Thrombosis journal · 2025Article
- Comprehensive biochemical, molecular and structural characterization of subtilisin with fibrinolytic potential in bioprocessing.Bioresources and bioprocessing · 2025Article
- Article
- Case Report: PROS1 (p.Leu584Arg) pathogenic mutation causes portal and superior mesenteric venous thromboembolism.Frontiers in cardiovascular medicine · 2023Article
- Direct oral anticoagulants for the treatment of atrial fibrillation in patients with hematologic malignancies.Journal of thrombosis and thrombolysis · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma levels of the anticoagulant cofactor protein S and PROS1 mutation are reported to impart increased risk of thromboembolism in European and south east Asian populations, but the relationship is not yet documented in Han Chinese in population-based study. Therefore, we undertook a case-control study of this relationship among patients with venous thromboembolism, and probed the genetic factors contributing to low protein S deficiency. Among the 603 consecutively recruited venous thromboembolism patients, 51 (8.5%) proved to be deficient in free protein S antigen (lower than 38.6 U/dl), among whom 30 cases were identified to have a causative mutation by direct sequencing. In contrast, six cases (1.0%) of the 584 healthy controls had low free antigen levels, among whom direct sequencing confirmed disease-causing gene mutations in four controls (0.7%). After adjusting for age and gender, the odds ratio of developing venous thromboembolism in individuals with protein S deficiency based on free protein S tests was 8.1 (95% CI = 3.6-19.9,
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