Evidence map›Paper›PMID 35816231›Full record

ArticleDrug delivery and translational research2023

Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles.

Federica De Lorenzi, Larissa Yokota Rizzo, Rasika Daware, Alessandro Motta, Maike Baues, Matthias Bartneck, Michael Vogt, Marc van Zandvoort, Leonard Kaps, Qizhi Hu and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Drug delivery and translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
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  4. Photothermal FeJournal of nanobiotechnology · 2024
    Article
  5. Review
  6. Review
  7. Vasculature organotropism in drug delivery.Advanced drug delivery reviews · 2023
    Review
  8. Review
  9. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Federica De LorenziDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Larissa Yokota RizzoDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Rasika DawareDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Alessandro MottaDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Maike BauesDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Matthias BartneckClinic for Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine (Internal Medicine III), RWTH Aachen University Clinic, Aachen, Germany.
Michael VogtInterdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University Clinic, Aachen, Germany.
Marc van ZandvoortInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University Clinic, Aachen, Germany.
Leonard KapsDepartment of Medicine, University Medical Center Mainz, Mainz, Germany.
Qizhi HuCristal Therapeutics, Maastricht, The Netherlands.
Marielle ThewissenCristal Therapeutics, Maastricht, The Netherlands.
Luca CasettariDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Cristianne J F RijckenCristal Therapeutics, Maastricht, The Netherlands.
Fabian KiesslingInstitute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Alexandros Marios SofiasDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany.
Twan LammersDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging (ExMI), RWTH Aachen University Clinic, Aachen, Germany. tlammers@ukaachen.de.
RWTH Aachen University · DECristal Therapeutics (Netherlands) · NLFraunhofer Institute for Digital Medicine · DEMaastricht University · NLUniversitätsklinikum Aachen · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DEUniversity of Urbino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymeric micelles are increasingly explored for tumor-targeted drug delivery. CriPec® technology enables the generation of core-crosslinked polymeric micelles (CCPMs) based on thermosensitive (mPEG-b-pHPMAmLac

Indexed as

Integrin beta3MicellesCell Line, TumorDrug Delivery SystemsPeptides, CyclicPolymersTissue DistributionIntegrin beta3MicellesPeptides, CyclicPolymersCore-crosslinked polymeric micellesCriPec®Cyclic arginine-glycine-aspartic acid (cRGD)NanomedicineNanoparticlesTumor targeting

Identifiers

PMID35816231
PMCPMC10102119
OpenAlexW4285043204

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.